RecruitingNot ApplicableNCT07216846

The Geriatric Emergency Department Pharmacologic Harm Prevention Project

Sponsor

Florida Atlantic University

Enrollment

1,000 participants

Start Date

Jan 1, 2026

Study Type

INTERVENTIONAL

Conditions

Adverse Drug Events Poly Pharmacy Fall Pharmacogenomic Drug Interaction Fall Accident Pharmacogenomic Testing

Summary

The goal of this project is to determine whether pharmacogenomic testing (using participants' DNA) can help optimize medication prescribing and reduce side effects in older adults taking five or more medications. The main questions it aims to answer are: * Can DNA-based prescribing reduce medication-related side effects, especially falls and fall-related injuries? * Does providing pharmacogenomic results to primary care physicians improve medication safety compared with usual care? Researchers will compare two groups: 1. DNA Care Pathway: Physicians receive patients' DNA results to guide prescribing. 2. Emergency Department Care Pathway: Physicians provide usual care; DNA results are shared only after study completion. Participants will: * Provide a cheek swab sample for DNA analysis (1 minute). * Receive monthly follow-up phone calls for 6 months to track falls, injuries, medication changes, and side effects. * Complete a fall and medication calendar. * Allow researchers to review primary care physician medical records for study outcomes. Approximately 1,000 participants will take part, with follow-up lasting about 6-7 months.

Eligibility

Min Age: 65 YearsMax Age: 110 Years

Inclusion Criteria1

Patients over the age of 65 with a ground level fall

Exclusion Criteria1

hospice and/or DNR status.

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Interventions

OTHERDNA care pathway

Pharmacogenomic test results will be transmitted to the participant's primary care physician to support medication optimization and prescribing decisions. Follow-up assessments will be conducted by telephone approximately 14 days after enrollment and then monthly for six months. These structured interviews will capture information on falls, fall-related injuries, medication changes, adverse drug effects, and new medical conditions. Participants will also complete a monthly calendar to document medication changes, falls, and fall-related injuries. Medical records from the participant's primary care physician will be reviewed for corroborating information on falls, fall-related injuries, medication changes, medication-related side effects, and newly diagnosed medical problems.