A Study of JNJ-90301900 in Combination With Chemoradiation Therapy in Participants With Locally Advanced Head and Neck Squamous Cell Carcinoma

This study is testing an experimental drug called JNJ-90301900 combined with the standard treatment of chemotherapy plus radiation for people with locally advanced head and neck squamous cell carcinoma (HNSCC) — a type of cancer in the mouth, throat, or voicebox that has spread to nearby tissue or lymph nodes but not yet to distant organs. **You may be eligible if...** - You have confirmed squamous cell carcinoma of the oral cavity, oropharynx (p16 negative), hypopharynx, or supraglottic larynx - Your cancer is Stage III, IVA, or IVB - You are a candidate for standard chemoradiation treatment (chemotherapy combined with radiation) - You have at least one measurable tumor - You are generally well enough for treatment (ECOG 0 or 1) **You may NOT be eligible if...** - Your cancer originated in the nasopharynx, sinuses, salivary glands, thyroid, skin, or is of unknown primary site - Your cancer is at Stage 0, I, II, or has spread to distant organs (Stage IVC) - Your cancer has come back (recurrent) or you have a second simultaneous head and neck cancer - You cannot safely receive cisplatin chemotherapy Talk to your doctor to see if this trial is right for you.