Effects of a 5-Week Probiotic Supplementation Intervention on Markers of Delayed Onset Muscle Soreness
University of Minnesota
24 participants
Feb 5, 2026
INTERVENTIONAL
Conditions
Summary
The purpose of this study is to evaluate how probiotic supplementation (PS) influences post-exercise recovery in healthy, physically active young adults. Researchers aim to determine if the Lactobacillus casei probiotic strain reduces symptoms of delayed onset muscle soreness (DOMS) based on perceived muscle soreness, pressure pain threshold, and power output following exercise induced muscle damage (EIMD).
Eligibility
Inclusion Criteria3
- complete a minimum of 150 minutes a week of at least moderate intensity exercise in either an endurance-based or resistance-based training style based on a self-reported physical activity over the past month
- good general health with no injuries or health conditions that would affect physical activity
- willing to abstain from consistent NSAID use and other probiotic supplements over the course of this study
Exclusion Criteria4
- known musculoskeletal injuries or physical limitations that could interfere with performing the designated physical activity required
- underlying conditions that could place them at an increased risk during exercise such as cardiovascular, respiratory, or metabolic diseases
- currently take a probiotic supplement, are prescribed and taking an antibiotic during the intervention, or report using NSAIDs or steroids within the recovery time window
- report using an NSAID more than twice a week on a regular basis
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Interventions
Probiohealth is the manufacturer of this strain and they use a stringent quality control program that utilizes a multi point product variability check system.
The brand name of placebo capsules that will be used in this study is Magic Bullet Placebo Capsules. This placebo is manufactured by Progressive Placebo as stated on the product label.
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT07219498