Exercise-priming of CBT for Depression: the CBT+ Trial

This study — called CBT+ — is testing whether doing an acute bout of exercise right before a cognitive behavioral therapy (CBT) session helps people get more out of therapy for depression. The idea is that exercise may "prime" the brain to be more receptive to psychological treatment. **You may be eligible if...** - You have been diagnosed with major depressive disorder (MDD) - Your depression is at least mildly severe (Hamilton Rating Scale score of 8 or higher) - You are either not on mental health medications OR have been on the same stable medications for 8 weeks - You are physically safe to exercise (cleared by physical activity questionnaire) **You may NOT be eligible if...** - You have conditions that prevent safe exercise participation - You have recently changed your psychiatric medications - You have severe or unstable medical conditions Talk to your doctor to see if this trial is right for you.