NIRS Monitoring in the NICU and AKI
Near Infrared Spectroscopy (NIRS) Monitoring as an Early Predictor of Acute Kidney Injury (AKI) in a Vulnerable Neonatal Intensive Care Unit (NICU) Population
NYU Langone Health
100 participants
Nov 1, 2025
INTERVENTIONAL
Conditions
Summary
The primary objective of this study is to describe the pattern of renal tissue oxygen saturation (SrSO2) using near-infrared spectroscopy (NIRS) in premature infants \<30 weeks gestational age. The secondary objective of this study is to evaluate prenatal and postnatal risk factors for acute kidney injury (AKI) in premature infants \<30 weeks gestational age. The investigators will also compare various rates of complications including death, length-of-stay, and prolonged duration of mechanical ventilation, among others.
Eligibility
Inclusion Criteria2
- Any neonate less than 30 weeks in gestational age
- Willingness and capacity of both adult parents/guardians to sign consent
Exclusion Criteria4
- An infant with known congenital anomalies of the kidney (i.e., grade 4 or 5 vesicoureteral reflux (VUR), posterior urethral valves, moderate or severe hydronephrosis, autosomal recessive polycystic kidney disease (ARPKD), bilateral renal agenesis or dysplasia)
- Age \>30 weeks gestational age
- Age \<24 weeks and \<500 grams (will be excluded due to sensitivity of skin in this vulnerable population).
- Clinician's decision that NIRS is not suitable due to the patient's clinical condition
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Interventions
The renal NIRS device is a non-invasive tool that uses near-infrared light to measure oxygen saturation various tissues. Renal NIRS sensors will be placed by 24 hours of the participants' admission.
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT07222722