Handgrip Training and Brain Blood Flow Regulation
Florida State University
40 participants
Oct 27, 2025
INTERVENTIONAL
Conditions
Summary
This study aims to investigate the effect of isometric handgrip training on brain blood vessel function in physically inactive adults. Isometric handgrip training is a promising strategy for lowering blood pressure and improving vascular health, but no previous investigations have studied the effect of training on markers of brain blood vessel function. Based on previous work showing improvements in vascular function after isometric handgrip training, we hypothesize that isometric handgrip training will improve key markers of cerebrovascular function.
Eligibility
Inclusion Criteria4
- to 35 years old
- Body mass index ≤30 kg/m2 (without obesity)
- Physically inactive (not meeting the current recommendations of ≥150 minutes per week of moderate-to-vigorous aerobic exercise and not ≥2 days per week of resistance training) in last 6 months
- Have a smartphone and are willing to download mobile applications used in this project
Exclusion Criteria4
- Having an overt chronic condition (e.g., cardiovascular, cerebrovascular, etc.)
- Being pregnant, planning to become pregnant, or breastfeeding/lactating
- Regular use of nicotine products in the past 6 months
- Recent head injury/trauma or concussion
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Interventions
Handgrip training 3 days per week for 8 weeks
Locations(1)
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NCT07223645