Hormonal Optimization: Late vs. Immediate Start After Discontinuation of Oral Contraceptives in Assisted Reproductive technologY (HOLIDAY)
A Randomized Blinded Controlled Trial Assessing Hormonal Optimization: Late vs. Immediate Start After Discontinuation of Oral Contraceptives in Assisted Reproductive technologY (HOLIDAY)
Shady Grove Fertility Reproductive Science Center
394 participants
Feb 25, 2026
INTERVENTIONAL
Conditions
Summary
HOLIDAY is a two-arm, parallel-group, multi-center, randomized trial in which subjects undergoing planned oocyte cryopreservation will be randomized to receive either a 2-month pause of Combined Hormonal Contraceptives (CHC) or immediate start (without a pause).
Eligibility
Inclusion Criteria3
- Ovary-bearing individuals 18 to 40 years of age.
- BMI < 40 kg/m2
- Non-smoker for at least 3 months prior to study enrollment.
Exclusion Criteria3
- BMI greater than or equal to 40 kg/m2
- Current Smoker
- Any contraindications to ovarian stimulation or outpatient egg retrieval under anesthesia
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Interventions
Subjects in the study arm will be asked to discontinue combined hormonal contraceptives (CHC) for 2 months prior to planned oocyte cryopreservation
Locations(3)
View Full Details on ClinicalTrials.gov
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NCT07225660