RecruitingNot ApplicableNCT07226609

A Dietary Study for People With Multiple Myeloma

A Decentralized Randomized Dietary Trial in Newly Diagnosed Multiple Myeloma - NUTRIVENTION5

Sponsor

Memorial Sloan Kettering Cancer Center

Enrollment

220 participants

Start Date

Nov 4, 2025

Study Type

INTERVENTIONAL

Conditions

Multiple Myeloma

Summary

The purpose of the study is to find out whether a dietary intervention can affect treatment response and/or quality of life for people with newly diagnosed multiple myeloma receiving standard induction chemotherapy with daratumumab (or isatuximab), lenalidomide, bortezomib, and dexamethasone (DRVd). The researchers will measure quality of life by having participants complete questionnaires. The study will investigate the effects of diet on quality of life, treatment response, and other disease, microbiome, and immune markers.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study looks at whether a specific diet can improve treatment outcomes for people newly diagnosed with multiple myeloma (a type of blood cancer) who are starting standard chemotherapy. Researchers want to know if dietary changes can help the cancer reach a deeper remission. **You may be eligible if...** - You have been newly diagnosed with multiple myeloma, confirmed by bone marrow biopsy - You are 18 or older - You are planned to receive a standard 4-drug chemotherapy regimen (DRVd) for four 28-day cycles - You can enroll before the 21st day of your first treatment cycle - You are being treated at a site that can test for bone marrow minimal residual disease **You may NOT be eligible if...** - You have already completed your first cycle and passed day 21 - You are not able to complete the study procedures - You have received more than one cycle of certain prior treatments Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERnutrition counseling and coaching

In addition to individual counseling, patients will be able to join optional group sessions every 2 weeks as well as text message check-ins for survey completion reminders. Patients will receive 12 frozen, fixed pre-made lunch and dinner shipped to their home weekly from Modify Health for 12 weeks.

OTHERdietary guidelines, research dietitian visit

Participants will have phone calls with a member of the study team every 4 weeks as well as text message check-ins for survey completion reminders. At the end of standard induction chemotherapy, participants will have a phone call or video call with a dietitian

BEHAVIORALQuestionnaires

Block FFQ survey, EORTC QLQ C30 survey, EORTC MY20 survey, Pre intervention survey, Post intervention survey

OTHERFrozen pre-prepared meals

Patients will receive 12 frozen, fixed pre-made lunch and dinner shipped to their home weekly from Modify Health for 12 weeks.