RecruitingNCT07227116

Evaluating the Status of Complex Aneuploidy to Locate Additional Transferrable Embryos

ESCALATE: Evaluating the Status of Complex Aneuploidy to Locate Additional Transferrable Embryos


Sponsor

Shady Grove Fertility Reproductive Science Center

Enrollment

280 participants

Start Date

Nov 1, 2025

Study Type

OBSERVATIONAL

Conditions

Summary

This study aims to evaluate the reproductive potential of embryos classified as "complex aneuploid" (involving three or more abnormal chromosomes) or "chaotic" (six or more abnormal chromosomes) through preimplantation genetic testing for aneuploidy (PGT-A). Specifically, we seek to determine whether embryos initially reported as having multiple chromosomal abnormalities might still have the potential for normal chromosomal composition, the opportunity for transfer, and ultimately, the potential to achieve a live birth through re-biopsy and reanalysis. Key Information: This portion of the study seeks your consent for the re-biopsy and genetic reanalysis of the embryos only. It does not yet include consent for potential future transfer. Participation remains completely voluntary, and your decision will not affect your current or future care. We deeply appreciate your support and commitment to advancing fertility research.


Eligibility

Inclusion Criteria1

  • Having ≥ 1 embryo classified as whole chromosome chaotic or complex aneuploid of 3 or more chromosomes following preimplantation genetic testing for aneuploidy using an NGS based platform Signed informed consent

Exclusion Criteria1

  • Embryos not meeting complex/chaotic criteria Patients declining consent

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Locations(12)

IVF Florida Reproductive Associates

Margate, Florida, United States

Shady Grove Fertility

Atlanta, Georgia, United States

Fertility Center of Illinois

Highland Park, Illinois, United States

Shady Grove Fertility

Rockville, Maryland, United States

Shady Grove Fertility

Towson, Maryland, United States

Shady Grove Fertility

Cary, North Carolina, United States

Shady Grove Fertility

Cary, North Carolina, United States

Shady Grove Fertility

Chesterbrook, Pennsylvania, United States

Shady Grove Fertility

Fairfax, Virginia, United States

Shady Grove Fertility

Norfolk, Virginia, United States

Shady Grove Fertility

Richmond, Virginia, United States

SGFertility Chile Medicina Reproductiva

Santiago, Santiago Metropolitan, Chile

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NCT07227116