RecruitingNCT07227441

Chronic Infections and Inflammation in ME/CFS: An Observational Study

Sponsor

University of California, San Francisco

Enrollment

200 participants

Start Date

Jan 1, 2026

Study Type

OBSERVATIONAL

Conditions

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

Summary

CHIIME is a study of people who have myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). People who do not have this condition will also be enrolled. Volunteers will be observed and sampled over time to identify the long-terms biological drivers and impact of their condition. The overall goal is to understand the biological and physiological mechanisms that are driving this condition.

Eligibility

Min Age: 18 Years

Inclusion Criteria3

Willing and able to provide written informed consent
At least 18 years of age
Either: (1) a reported diagnosis of ME/CFS or (2) no history of ME/CFS or other infection-associated chronic conditions (healthy control)

Exclusion Criteria5

Self reported or documented chronic anemia with hemoglobin \<9 g/dL
Known HIV, hepatitis B, or hepatitis C infection
Diagnosis of an infection-associated chronic condition other than ME/CFS or Long COVID (e.g. chronic Lyme disease, post-Ebola syndrome, etc.)
Serious medical or psychiatric illness that, in the opinion of the site investigator, would interfere with the ability to adhere to study requirements or to give informed consent
Active drug or alcohol use or dependence that, in the opinion of the PI, would interfere with adherence to study requirements or to give informed consent

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