RecruitingNCT07227753

The Association Between Gut Microbiota Diversity and Postpartum Depression

The Association Between Gut Microbiota Diversity and Postpartum Depression: A Prospective Pilot Study


Sponsor

Massachusetts General Hospital

Enrollment

30 participants

Start Date

Nov 17, 2025

Study Type

OBSERVATIONAL

Conditions

Summary

This study aims to examine whether naturally occurring bacteria in the gastrointestinal tract are associated with mood changes following childbirth, including postpartum depression. Biological samples will be collected before and after delivery to determine whether specific patterns in gut bacterial composition are linked to emotional states. The purpose of the research is to improve understanding of whether such microbial changes can help identify individuals at higher risk for postpartum depression, enabling earlier recognition and intervention.


Eligibility

Sex: FEMALEMin Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study looks at whether differences in gut bacteria (microbiome) during and after pregnancy are linked to postpartum depression. Researchers will collect rectal swab samples at the time of a planned cesarean delivery and follow participants to track mood symptoms afterward. **You may be eligible if...** - You are 18 or older - You are at least 36 weeks pregnant and planning a cesarean delivery - You can understand the study procedures and give consent - You are willing to provide a rectal swab sample **You may NOT be eligible if...** - You have a gastrointestinal condition or have recently taken antibiotics that could change your gut microbiome - You have a severe mental illness (such as schizophrenia, bipolar disorder, or major depression with psychosis) - You took antidepressants, antibiotics, or fish oil supplements during pregnancy - You refuse to provide rectal swab samples Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Locations(1)

Meikun Wang

Boston, Massachusetts, United States

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NCT07227753


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