The Association Between Gut Microbiota Diversity and Postpartum Depression
The Association Between Gut Microbiota Diversity and Postpartum Depression： A Prospective Pilot Study
Massachusetts General Hospital
30 participants
Nov 17, 2025
OBSERVATIONAL
Conditions
Summary
This study aims to examine whether naturally occurring bacteria in the gastrointestinal tract are associated with mood changes following childbirth, including postpartum depression. Biological samples will be collected before and after delivery to determine whether specific patterns in gut bacterial composition are linked to emotional states. The purpose of the research is to improve understanding of whether such microbial changes can help identify individuals at higher risk for postpartum depression, enabling earlier recognition and intervention.
Eligibility
Inclusion Criteria4
- Age 18 years or older
- Gestational age at least 36 weeks, planned cesarean delivery
- Ability to understand study procedures and provide informed consent
- Voluntary agreement to participate in the study
Exclusion Criteria4
- Gastrointestinal disorders or recent antibiotic use that significantly alters gut microbiome
- Diagnosis of severe mental illness such as schizophrenia, schizoaffective disorder, bipolar disorder, or major depressive disorder with psychotic features
- Medication use during pregnancy known to influence gut microbiota, including antidepressants, antibiotics, or fish oil
- Refusal to provide rectal swab samples or inability to complete follow-up assessments
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT07227753