Whole Body MRI for Non-invasive Lesion Detection and Therapy Follow-up: Study With Patients With Radiographic axSpA and Non-radiographic axSpA
Research on a New Disease Activity Assessment System for axSpA Based on Whole-body Magnetic Resonance Imaging Cohort
The First Affiliated Hospital with Nanjing Medical University
100 participants
Jan 1, 2022
OBSERVATIONAL
Conditions
Summary
This study aims to further improve and expand the WB-MRI imaging evaluation cohort of axSpA patients to complete dynamic follow-up and condition assessment. Based on the WB-MRI features, the association of WB-MRI signs with disease activity, inflammation, and structural damage will be analyzed. At the same time, in-depth data mining was conducted and machine learning was used to construct a new axSpA disease activity assessment model based on WB-MRI data, and the accuracy and reliability of the model were clearly evaluated in the discovery cohort and validation cohort.
Eligibility
Inclusion Criteria4
- Include newly referred patients if:
- The onset of symptoms (back pain/arthritis/enthesitis) < 45 years
- Undiagnosed disease with the following symptoms:
- chronic back pain (duration of back pain more than 3 months) and/or peripheral arthritis (asymmetric arthritis/predominantly of the lower limbs) and/or enthesitis and/or dactylitis
Exclusion Criteria1
- And diagnosed with non-radiographic or radiographic axial SpA
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Interventions
These studies will be performed on a 3Tesla (T) MR system (Achieva, Philips Medical Systems) for all patients.
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT07230327