RecruitingPhase 1NCT07230600
AD-SVF Therapy for Refractory Endometrial Infertility
Autologous Adipose-derived Stromal Vascular Fraction Therapy for Refractory Endometrial Infertility
Sponsor
The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Enrollment
10 participants
Start Date
Nov 1, 2025
Study Type
INTERVENTIONAL
Conditions
Summary
The purpose of this study is to initially explore the efficacy of adipose-derived stromal vascular fraction (AD-SVF) therapy in the treatment of refractory endometrial infertility.
Eligibility
Sex: FEMALEMin Age: 22 YearsMax Age: 45 Years
Inclusion Criteria5
- refractory thin endometrium (endometrial thickness < 6 mm on the day of ovulation or the day of endometrial transformation during a hormone replacement cycle) and/or moderate to severe intrauterine adhesion；
- Inability to undergo autologous bone marrow stem cells-scaffold (BMSC) transplantation due to failed bone marrow aspiration, or lack of significant effect following the BMSC treatment;
- with fertility intentions;
- normal ovarian function or availability of cryopreserved embryos;
- 18kg/m\^2 < body mass index (BMI) < 30kg/m\^2;
Exclusion Criteria7
- Chromosomal karyotype abnormalities in one spouse;
- Severe endometriosis, uterine fibroids affecting the uterine cavity morphology, or uterine malformations;
- Abnormalities in coagulation function, hepatic or renal function, or other underlying conditions deemed by the investigator to potentially impact the study's progression (uncontrolled hypertension, diabetes, autoimmune diseases, etc.);
- Contraindications for pregnancy;
- Contraindications for hormonal cycle therapy;
- History of pelvic tumors;
- Simultaneous participation in other clinical studies.
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Interventions
BIOLOGICALAD-SVF
AD-SVF is isolated and extracted from adipose tissue for intrauterine infusion therapy.
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT07230600