RecruitingNCT07230691

A Study of Clinical Outcomes in Participants With EGFR Mutated Advanced Non-Small Cell Lung Cancer (NSCLC) in a Real-World Setting

Prospective, Multi Country, Observational Study of Clinical Outcomes in EGFR-mutated, Advanced Non-Small Cell Lung Cancer (NSCLC) Patients Treated With Approved Amivantamab-containing Regimens Under Standard Clinical Practice

Sponsor

Janssen Research & Development, LLC

Enrollment

380 participants

Start Date

Dec 3, 2025

Study Type

OBSERVATIONAL

Summary

The purpose of this study is to describe the clinical and health-related outcomes of amivantamab-containing regimens for the treatment of common epidermal growth factor receptor (EGFR) mutated non-small cell lung cancer (NSCLC; most common type of lung cancer) in a real-world setting. Metastatic NSCLC is when this disease spreads to other parts of body. NSCLC may occur due to mutations (changes) in many genes including epidermal growth factor receptor (EGFR).

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This is a real-world observational study following people with a specific type of advanced lung cancer — non-small cell lung cancer with EGFR mutations — who are receiving a drug called amivantamab as part of their standard care. Researchers want to understand how this treatment performs in everyday clinical practice. **You may be eligible if...** - You have advanced non-small cell lung cancer with a confirmed EGFR mutation (specifically exon 19 deletion or exon 21 L858R) - Your doctor has decided to treat you with amivantamab as part of your standard care - Your treatment aligns with the approved uses of amivantamab in your country **You may NOT be eligible if...** - You do not have the specific EGFR mutation types listed above - Amivantamab is not an appropriate treatment option for you per your doctor's judgment - You are participating in another interventional clinical trial Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Locations(48)

Klinikum Klagenfurt am Worthersee

Klagenfurt, Austria

Fakultni nemocnice Brno

Brno, Czechia

Fakultni nemocnice Hradec Kralove

Hradec Králové, Czechia

Fakultni nemocnice Olomouc

Olomouc, Czechia

Fakultni Thomayerova nemocnice

Prague, Czechia

MVZ am Klinikum Aschaffenburg Onkologie

Aschaffenburg, Germany

Evangelisches Klinikum Bethel

Bielefeld, Germany

Augusta Kliniken Bochum Hattingen

Bochum, Germany

Klinikum Chemnitz gGmbH

Chemnitz, Germany

Haematologie u Onkologie Koeln MV Zentrum

Cologne, Germany

Kliniken Essen-Mitte; Evangelische Huyssens-Stiftung

Essen, Germany

Facharztzentrum Eppendorf

Hamburg, Germany

Onkologie am Raschplatz

Hanover, Germany

Klinikum Region Hannover Klinikum Siloah

Hanover, Germany

Lungenklinik Hemer

Hemer, Germany

Klinikum Konstanz

Konstanz, Germany

MVZ Onkologie Groschek Keller

Stolberg, Germany

Bundeswehrkrankenhaus Ulm

Ulm, Germany

Rabin Medical Center

Petah Tikva, Israel

Sheba Medical Center

Ramat Gan, Israel

Assuta MC

Tel Aviv, Israel

Ospedale San Giuseppe Moscati di Avellino

Avellino, Italy

Oncologia Medica - Irccs - Istituto Tumori Giovanni Paolo II

Bari, Italy

Istituto di Candiolo, IRCCS

Candiolo, Italy

PO G.Rodolico, AOU Policlinico-Vittorio Emanuele Catania

Catania, Italy

Azienda Ospedaliera Pugliese Ciaccio Catanzaro

Catanzaro, Italy

Ospedale Policlinico San Martino IRCCS

Genova, Italy

Azienda Ospedaliera ''Vito Fazzi''

Lecce, Italy

San Raffaele Hospital

Milan, Italy

Istituto Dei Tumori Di Milano

Milan, Italy

European Institute of Oncology

Milan, Italy

ASST Grande Ospedale Metropolitano Niguarda

Milan, Italy

Fondazione G Pascale Istituto Nazionale Tumori IRCCS

Naples, Italy

Azienda Ospedaliero Universitaria Maggiore della Carita di Novara

Novara, Italy

ASL Gallura - Ospedale Giovanni Paolo II

Olbia, Italy

Azienda Ospedaliero Universitaria Policlinico Paolo Giaccone

Palermo, Italy

A.O.R Villa Sofia Cervello

Palermo, Italy

Azienda Ospedaliero Universitaria di Sassari

Sassari, Italy

Ospedali Riuniti Di Ancona

Torrette-Ancona, Italy

Hosp Reina Sofia

Córdoba, Spain

Hosp. Univ. Lucus Augusti

Lugo, Spain

Hospital Universitario Virgen Rocio

Seville, Spain

Hosp. Clinico Univ. de Valladolid

Valladolid, Spain

Eastbourne District General Hospital

Eastbourne, United Kingdom

New Cross Hospital

Heath Town, United Kingdom

Royal Marsden Hospital

London, United Kingdom

The Christie NHS Foundation Trust Christie Hospital

Manchester, United Kingdom

Royal Marsden Hospital (Sutton)

Sutton, United Kingdom

View Full Details on ClinicalTrials.gov

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NCT07230691