RecruitingPhase 1NCT07230834

Intravitreal (IVT) Pozelimab for Geographic Atrophy (GA) in Adult Participants

A Phase 1 Dose-Escalation and Repeated-Dose Study of the Safety and Tolerability of Intravitreal Pozelimab in Participants With Geographic Atrophy


Sponsor

Regeneron Pharmaceuticals

Enrollment

54 participants

Start Date

Jan 19, 2026

Study Type

INTERVENTIONAL

Conditions

Summary

This study is researching an experimental drug called pozelimab (called "study drug"). The study is focused on people with a condition where certain parts of the eye's retina stop working over time, which can make it harder to see. This is called geographic atrophy (GA). The aim of the study is to see how safe and tolerable the study drug is when used as an injection in the eye. The study is looking at several other research questions, including: * What side effects may happen from taking the study drug * How much study drug is in the blood and the fluid in the eye at different times * Whether the body makes antibodies against the study drug (which could make the drug less effective or could lead to side effects)


Eligibility

Min Age: 50 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a drug called Pozelimab for people with geographic atrophy (ga). The study is currently recruiting participants at 8 locations.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGPozelimab

Administered per the protocol


Locations(9)

Colorado Retina Associates

Lakewood, Colorado, United States

Ophthalmic Consultants of Boston

East Weymouth, Massachusetts, United States

Austin Retina Associates

Austin, Texas, United States

Retina Foundation of the Southwest

Dallas, Texas, United States

Retina Consultants Texas

The Woodlands, Texas, United States

Arensia Exploratory Medicine at the Research Institute of Clinical Medicine

Tbilisi, Georgia

Emanuelli Research and Development Center

Arecibo, Puerto Rico

ARENSIA Clinics SRL

Bucharest, Romania

Arensia Exploratory Medicine Clinic at Country Hospital Cluj-Napoca

Cluj-Napoca, Romania

View Full Details on ClinicalTrials.gov

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NCT07230834


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