RecruitingPhase 3NCT07231419

Evaluation of Efficacy and Safety of Suzetrigine (SUZ) for Pain Associated With Diabetic Peripheral Neuropathy

A Phase 3, Randomized, Double-blind, Placebo-Controlled Study of the Efficacy and Safety of Suzetrigine in Subjects With Pain Associated With Diabetic Peripheral Neuropathy

Sponsor

Vertex Pharmaceuticals Incorporated

Enrollment

734 participants

Start Date

Nov 21, 2025

Study Type

INTERVENTIONAL

Conditions

Diabetic peripheral neuropathic pain

Summary

The purpose of this study is to evaluate the efficacy, safety, and tolerability of Suzetrigine in participants with pain associated with diabetic peripheral neuropathy (DPN).

Eligibility

Min Age: 18 YearsMax Age: 80 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a drug called Placebo (matched to SUZ) and a drug called Suzetrigine for people with diabetic peripheral neuropathic pain. The study is currently recruiting participants at 75 locations. People eligible for this study include aged 18 Years to 80 Years.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGSuzetrigine

Tablets for oral administration

DRUGPlacebo (matched to SUZ)

Placebo matched to SUZ for oral administration.

Locations(75)

Central Research Associates, LLC

Birmingham, Alabama, United States

Accel Research - Birmingham

Birmingham, Alabama, United States

AMR Mobile

Mobile, Alabama, United States

Sun City Clinical Research

Glendale, Arizona, United States

Scottsdale Clinical Trials

Scottsdale, Arizona, United States

Lynn Institute of the Ozarks

Little Rock, Arkansas, United States

Hope Clinical Research

Canoga Park, California, United States

Marvel Clinical Research

Huntington Beach, California, United States

Eximia Research-CA, LLC

La Mesa, California, United States

Long Beach Research Institute

Long Beach, California, United States

Paradigm Clincial Research - Modesto

Modesto, California, United States

Pasadena Clinical Trials

Pasadena, California, United States

Artemis Institute for Clinical Research - Riverside

Riverside, California, United States

Velocity Clinical Research -San Bernardino

San Bernardino, California, United States

Alpine Clinical Research Center

Boulder, Colorado, United States

Paradigm Clinical Research - Wheat Ridge

Wheat Ridge, Colorado, United States

Chase Medical Research

Waterbury, Connecticut, United States

Velocity Clinical Research - Washington DC

Washington D.C., District of Columbia, United States

Neurology Offices of South Florida, PLLC

Boca Raton, Florida, United States

Accel Research - Deland

DeLand, Florida, United States

Velocity Clinical Research - Hallandale Beach

Hallandale, Florida, United States

CNS Healthcare - Jacksonville

Jacksonville, Florida, United States

Health Awareness, Inc. - Jupiter

Jupiter, Florida, United States

3Sync Research -Miami Lakes

Miami Lakes, Florida, United States

Aqualane Clinical Research

Naples, Florida, United States

CNS Healthcare - Orlando

Orlando, Florida, United States

Suncoast Clinical Research - Palm Harbor

Palm Harbor, Florida, United States

3Sync Research - Palm Springs

Palm Springs, Florida, United States

Health Awareness, Inc. - Port St. Lucie

Port Saint Lucie, Florida, United States

ClinCloud - Viera

Viera, Florida, United States

Conquest Clinical Research - Winter Park

Winter Park, Florida, United States

Atlanta Center for Medical Research

Atlanta, Georgia, United States

Accel Research - Decatur

Decatur, Georgia, United States

Javara Inc./Privia Medical Group - Fayetteville, GA

Fayetteville, Georgia, United States

Velocity Clinical Research - Savannah

Savannah, Georgia, United States

Healthcare Research Network - Flossmoor IL

Tinley Park, Illinois, United States

Velocity Clinical Research - Baton Rouge

Baton Rouge, Louisiana, United States

Velocity Clinical Research - Lafayette

Lafayette, Louisiana, United States

Velocity Clinical Research - Rockville

Rockville, Maryland, United States

Boston Clinical Trials

Boston, Massachusetts, United States

Quest Research Institute

Farmington Hills, Michigan, United States

Velocity Clinical Research - Gulfport

Gulfport, Mississippi, United States

SCLA Management - St. Louis Pain Consultants

Creve Coeur, Missouri, United States

Healthcare Research Network - Hazelwood MO

Hazelwood, Missouri, United States

AMR Kansas City

Kansas City, Missouri, United States

M3 Wake Research - Las Vegas

Las Vegas, Nevada, United States

CenExel AMRI

Toms River, New Jersey, United States

Brooklyn Clinical Research

Brooklyn, New York, United States

Velocity Clinical Research - Syracuse

East Syracuse, New York, United States

Mid Hudson Medical Research, PLLC

New Windsor, New York, United States

Rochester Clinical Research - Rochester

Rochester, New York, United States

Asheville Clinical Research

Asheville, North Carolina, United States

Monroe Biomedical research

Monroe, North Carolina, United States

West Clinical Research

Morehead City, North Carolina, United States

Velocity Clinical Research - Cleveland

Beachwood, Ohio, United States

Velocity Clinical Research - Cincinnati - Blue Ash

Cincinnati, Ohio, United States

Lynn Institute of Norman

Norman, Oklahoma, United States

Velocity Clinical Research - Medford

Medford, Oregon, United States

Velocity Clinical Research - Providence

East Greenwich, Rhode Island, United States

Velocity Clinical Research - Anderson

Anderson, South Carolina, United States

Coastal Carolina Research Center

North Charleston, South Carolina, United States

Velocity Clinical Research - Spartanburg

Spartanburg, South Carolina, United States

M3 Wake Research - Chattanooga

Chattanooga, Tennessee, United States

Holston Medical Group

Kingsport, Tennessee, United States

AMR Knoxville, TN

Knoxville, Tennessee, United States

CNS Healthcare - Memphis

Memphis, Tennessee, United States

Amarillo Medical Specialists LLP

Amarillo, Texas, United States

QCR - BioBehavioral Research of Austin

Austin, Texas, United States

Zenos Clinical Research

Dallas, Texas, United States

Fort Worth Endocrine Research Center

Fort Worth, Texas, United States

Epic Clinical Research

Lewisville, Texas, United States

Prime Clinical Research - Mansfield - US 287

Mansfield, Texas, United States

Clinical Trials of Texas, LLC

San Antonio, Texas, United States

AMR Norfolk

Norfolk, Virginia, United States

Velocity Clinical Research - Spokane

Spokane, Washington, United States

View Full Details on ClinicalTrials.gov

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NCT07231419

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