RecruitingNot ApplicableNCT07231484
Effects of Grape Consumption on the Immune-Gut Axis in Obesity
Effects of Grape Consumption on Immune and Gut Health in the Setting of Obesity
Sponsor
University of Missouri-Columbia
Enrollment
50 participants
Start Date
Dec 19, 2025
Study Type
INTERVENTIONAL
Conditions
Summary
This study is investigating the benefits of whole freeze-dried grape powder consumption on the immune-gut axis in adults with obesity.
Eligibility
Min Age: 30 YearsMax Age: 45 Years
Inclusion Criteria7
- Age: 30-45 years
- Obesity with BMI of 30-45 kg/m2
- Willingness to consume study foods
- Consistent diet and activity patterns for 4 weeks
- Weight stable (<5kg change over last 3 months)
- Non-smoker > 1 year or more
- Not currently consuming an extremely healthy diet
Exclusion Criteria14
- Study food allergies
- Regular consumption of grapes or grape-derived products
- Gastrointestinal disease and/or bariatric surgery
- Uncontrolled hypertension and blood pressure >180/110
- Diabetes
- Clinical Depression
- Illicit drug use
- History of alcohol or drug abuse
- Recent use of medications that affect immune function (e.g., corticosteroids)
- Recent consumption of antibiotics, prebiotics, probiotics, symbiotics, or dietary supplements containing fiber or phytochemicals
- Pregnant or lactating individuals
- HIV positivity
- Recent start of medications that affect metabolism or appetite
- Drug therapy for coronary artery disease, peripheral artery disease, congestive heart failure, or dyslipidemia
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Interventions
OTHERFreeze-dried grape powder
48 g/day oral consumption during the 4-week active period.
OTHERPlacebo powder
Isocaloric placebo matched to grape powder; oral consumption during the 4-week active period.
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT07231484
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