RecruitingPhase 2NCT07134335

UBT251 Injection Phase II Clinical Study (CKD)

A Phase II Clinical Study to Evaluate the Efficacy and Safety of UBT251 Injection in Obese/Overweight Chronic Kidney Disease (CKD) Population


Sponsor

The United Bio-Technology (Hengqin) Co., Ltd.

Enrollment

180 participants

Start Date

Sep 1, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

This multicenter, randomized, double-blind, placebo-controlled phase II clinical study to evaluate the efficacy and safety of UBT251 injection in obese/overweight chronic kidney disease (CKD) population


Eligibility

Min Age: 18 YearsMax Age: 75 Years

Plain Language Summary

Simplified for easier understanding

This study is testing a new injectable drug called UBT251 in people with chronic kidney disease (CKD) who have significant protein in their urine — a sign of kidney damage. The goal is to see if UBT251 can slow kidney disease progression. **You may be eligible if...** - You are 18–75 years old - You have a BMI of 24 kg/m² or higher - Your kidney filtration rate (eGFR) is between 45 and 90 mL/min/1.73m² - You have had significant protein in your urine (UACR between 300–5000 mg/g) consistently for at least 3 months - If you take blood pressure or kidney-protective medications (like ACE inhibitors, ARBs, or SGLT2 inhibitors), your dose has been stable for at least 4 weeks **You may NOT be eligible if...** - Your kidney function is severely impaired (eGFR below 45) or too high (above 90) - You have had recent changes in your kidney medications - You have other conditions that would make the study drug unsafe Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGUBT251

Subcutaneous injection once weekly

DRUGUBT251

Subcutaneous injection once weekly

DRUGUBT251

Subcutaneous injection once weekly


Locations(1)

Peking University First Hospital

Beijing, China

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NCT07134335


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