RecruitingPhase 3NCT07231497

Cognitive Strategies in Early Psychosis 1

Sponsor

University of Minnesota

Enrollment

103 participants

Start Date

Oct 31, 2025

Study Type

INTERVENTIONAL

Conditions

Healthy Participants Cognition

Summary

The goal of this clinical is to learn more about decision making in psychosis spectrum disorders, like schizophrenia. The investigators will ask people who do not have psychosis to take a single dose of modafinil and then complete some brain games on the computer that measure decision making. They hope to improve our understanding of psychosis to help people in the future. The main research questions are: Does a single dose of modafinil change how people play the brain games? Does a single dose of modafinil change brain activity? Participants will: Complete an interview and self-report questionnaires. Complete safety screening activities, like a blood draw, a urine drug test, and an alcohol breathalyzer test. Take a single dose of modafinil. Complete brain games while wearing an electroencephalography (EEG) cap, before and after taking the single dose of modafinil. EEG measures electrical activity in the brain.

Eligibility

Min Age: 18 YearsMax Age: 35 Years

Plain Language Summary

Simplified for easier understanding

This study is testing cognitive strategies — structured mental exercises and thinking techniques — to help people in the early stages of psychosis manage their symptoms. Psychosis is a condition where a person loses touch with reality, often involving hallucinations or disordered thinking. **You may be eligible if...** - You are fluent in English - Your estimated IQ is 70 or above - You are currently an outpatient (not hospitalized) and have been stable for at least one month - Your psychiatric medication doses have been stable for at least one month **You may NOT be eligible if...** - You are currently in a psychiatric crisis or hospitalized - Your medication has changed significantly in the past 30 days (beyond minor adjustments) - You have a condition that would prevent you from completing cognitive assessments - You are simultaneously enrolled in a conflicting study Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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