RecruitingPhase 1NCT07232420

A Study of BL-M24D1 in Patients With Locally Advanced or Metastatic Non-Small Cell Lung Cancer and Other Solid Tumors

A Phase I Clinical Study to Evaluate the Safety, Tolerability, Pharmacokinetic Characteristics and Preliminary Efficacy of BL-M24D1 for Injection in Patients With Locally Advanced or Metastatic Non-Small Cell Lung Cancer and Other Solid Tumors


Sponsor

Sichuan Baili Pharmaceutical Co., Ltd.

Enrollment

33 participants

Start Date

Nov 11, 2025

Study Type

INTERVENTIONAL

Summary

This study is an open, multicenter, non-randomized phase I clinical trial to evaluate the safety, tolerability, pharmacokinetic characteristics, and preliminary efficacy of BL-M24D1 in patients with locally advanced or metastatic non-small cell lung cancer and other solid tumors.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is testing a new drug called BL-M24D1 in people with advanced non-small cell lung cancer (NSCLC) or other solid tumors that have stopped responding to standard treatments. Researchers are testing safety at different doses and looking for early signs of effectiveness. **You may be eligible if...** - You are 18 years or older (up to 75 for Phase Ia) - You have locally advanced or metastatic NSCLC or another solid tumor - You have at least one measurable tumor - Standard treatments have failed or you cannot tolerate them - Your heart, kidneys, liver, and blood counts are in acceptable range - Your general health allows you to carry out normal activities (ECOG score 0 or 1) **You may NOT be eligible if...** - You have active, uncontrolled brain tumors - You have severe heart problems (ejection fraction below 50%) - You are pregnant or breastfeeding - You have had major surgery or severe infections recently - You are on certain other medications that may interact with the study drug Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGBL-M24D1

Administration by intravenous infusion for a cycle of 2 weeks.


Locations(1)

Sun Yat-sen University Cancer Center

Guangzhou, Guangdong, China

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NCT07232420