A Phase 2 Study to Evaluate the Efficacy, Safety and Pharmacokinetics of SHR-1139 in Patients With Moderate-to-severe Active Ulcerative Colitis

This study is testing a new drug called SHR-1139 for people with moderate-to-severe active ulcerative colitis — a chronic inflammatory bowel disease causing sores and inflammation in the large intestine. Researchers want to see how well it works and how safe it is. **You may be eligible if...** - You are between 18 and 75 years old - You have had ulcerative colitis for at least 90 days and it is currently active - You have symptoms including rectal bleeding - Previous treatments like steroids, immunosuppressants, or biologic drugs have not worked well enough **You may NOT be eligible if...** - You are under 18 or over 75 years old - You are underweight (BMI below 18) - Your disease is not currently active or has been controlled - You have Crohn's disease rather than ulcerative colitis - You have a serious infection, liver disease, or other major health condition - You are pregnant or breastfeeding Talk to your doctor to see if this trial is right for you.