RecruitingPhase 2NCT07239245

Study to Evaluate the Efficacy and Safety of Neo-Adjuvant TACE and Atezolizumab Plus Bevacizumab Therapy for High-Risk Recurrent Hepatocellular Carcinamo

Efficacy and Safety of Transarterial Chemoembolization (TACE) Combined With Atezolizumab Plus Bevacizumab in Neoadjuvant Therapy for Patients With Hepatocellular Carcinoma: an Open-label, Single-arm, Multicenter, Prospective, Phase II Clinical Study


Sponsor

Cancer Institute and Hospital, Chinese Academy of Medical Sciences

Enrollment

30 participants

Start Date

Nov 12, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

This is an open-label, single-arm, multicenter, prospective, phase II clinical study to evaluate the efficacy and safety of TACE combined with Atezolizumab and Bevacizumab as neoadjuvant treatment in Hepatocellular Carcinoma.


Eligibility

Min Age: 18 YearsMax Age: 75 Years

Plain Language Summary

Simplified for easier understanding

This study is testing whether giving a combination of a targeted blood vessel treatment (TACE — a procedure that blocks tumor blood supply) along with two immunotherapy drugs (atezolizumab and bevacizumab) before surgery can reduce the chances of liver cancer coming back in people who have high-risk features. **You may be eligible if...** - You are 18 to 75 years old with a biopsy-confirmed diagnosis of hepatocellular carcinoma (liver cancer) - Your cancer can be surgically removed, but you have features that make recurrence more likely — such as tumor larger than 5 cm, more than 3 tumors, blood vessel invasion, or poorly differentiated (aggressive) cancer cells - You have not received any prior cancer treatment **You may NOT be eligible if...** - Your cancer has already spread beyond the liver - You have poor liver function or other conditions making surgery unsafe - You have had previous liver cancer treatment Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGAtezolizumab

Atezolizumab will be administered by IV infusion at a fixed dose of 1200 mg on Day 1 of each 21-day cycle.

DRUGBevacizumab

Bevacizumab will be administered by IV infusion at a fixed dose of 15 mg/kg on Day 1 of each 21-day Cycle.

PROCEDURETransarterial chemoembolization (TACE)

TACE will be performed by clinical demand.


Locations(4)

Cancer Hospital Chinese Academy of Medical Science

Beijing, Beijing Municipality, China

Henan Cancer Hospital

Zhengzhou, Henan, China

The First Hospital of China Medical University

Shenyang, Liaoning, China

Shanxi Cancer Hospital

Taiyuan, Shanxi, China

View Full Details on ClinicalTrials.gov

For the most up-to-date information, visit the official listing.

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NCT07239245


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