The Role and Regulatory Mechanism of Germinal Center Immune Response in Hepatitis B Virus Infection

This research study is investigating how the immune system — specifically a structure called the germinal center — responds during chronic hepatitis B virus (HBV) infection. Researchers will collect tissue samples from liver, spleen, tonsil, or lymph node surgeries to better understand why some people clear the virus while others develop chronic infection. **You may be eligible if...** - You have been diagnosed with chronic hepatitis B virus infection - You need surgery on your liver, spleen, tonsils, or lymph nodes as part of your medical care - You understand the study process and are willing to provide written consent **You may NOT be eligible if...** - You also have hepatitis C, HIV, alcoholic liver disease, non-alcoholic fatty liver disease, or autoimmune liver disease - You have an immune system disorder or blood clotting condition Talk to your doctor to see if this trial is right for you.