Aspirin Continuation or Discontinuation in Conservative Treatment for Chronic Subdural Hematoma
Safety and Efficacy of Aspirin Continuation or Discontinuation in Conservative Treatment for Chronic Subdural Hematoma: A Randomized Clinical Trial
Tao Liu
143 participants
Oct 15, 2025
INTERVENTIONAL
Conditions
Summary
This clinical study aims to learn about the efficacy and safety of aspirin continuation or discontinuation in conservative treatment for chronic subdural hematoma. All participants received standard conservative treatment for chronic subdural hematoma, with a randomized intervention to either continue or discontinue aspirin administration. By participating in this study, participants can receive additional scientific guidance on aspirin medication management beyond routine conservative treatment, thereby optimizing individualized therapy.
Eligibility
Inclusion Criteria5
- Age ≥18 years, male or female;
- Confirmed diagnosis of chronic subdural hematoma (cSDH) by cranial CT and/or MRI;
- Intended for conservative management (i.e., no surgical evacuation indication at enrollment);
- Regular aspirin use at enrollment;
- Informed consent signed by the patient or legal representative.
Exclusion Criteria6
- Patients requiring emergency surgery to remove hematoma at enrollment;
- Concurrent use of other anticoagulants or antiplatelet agents that cannot be discontinued according to the study protocol;
- cSDH secondary to other diseases or conditions (e.g., excessive drainage from ventriculoperitoneal shunts, intracranial tumors);
- Active bleeding events or major cardiac events (e.g., acute myocardial infarction, unstable angina, or revascularization surgery) within 30 days prior to enrollment;
- Known bleeding disorders (e.g., hemophilia, severe thrombocytopenia);
- Individuals unable to provide informed consent or for whom completion of follow-up is anticipated to be difficult.
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Interventions
All participants received standard conservative treatment for chronic subdural hematoma, with a randomized intervention to continue aspirin administration. This group of participants received oral administration of aspirin at a dose of 100 mg per day.
All participants received standard conservative treatment for chronic subdural hematoma, with a randomized intervention to discontinue aspirin administration. This group of participants did not use aspirin during the treatment period.
Locations(2)
View Full Details on ClinicalTrials.gov
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NCT07240454