Supplementary Nerve Blocks Added to the Adductor Canal Block for Postoperative Pain Management in Primary Total Knee Arthroplasty: A Randomized Controlled Comparison of Sciatic, BiFeS, and IPACK Techniques
Comparison of the Effectiveness of "Sciatic Nerve", "Biceps Femoris Short Head (BiFeS)" and "Interspace Between the Popliteal Artery and the Capsule of the Posterior Knee (IPACK)" Blocks Added to the Adductor Canal Block for Postoperative Pain Control in Patients Undergoing Primary Total Knee Arthroplasty: A Prospective, Randomized Controlled Clinical Trial
Erzincan University
102 participants
Nov 1, 2025
INTERVENTIONAL
Conditions
Summary
Postoperative pain following total knee arthroplasty (TKA) is a significant clinical problem that delays early mobilization, reduces patient satisfaction, and increases analgesic requirements. The adductor canal block (ACB), which aims to provide analgesia while preserving motor function, is widely used in postoperative pain management after TKA. However, clinical and anatomical studies have demonstrated that ACB is effective only in the anteromedial sensory innervation of the knee and does not adequately block pain originating from the posterior knee capsule. This limitation reduces analgesic effectiveness, particularly in patients with a prominent posterior pain component. The sciatic nerve block has long been considered the gold standard for managing posterior knee pain. However, due to disadvantages such as motor weakness and delayed rehabilitation, current pain management protocols increasingly favor motor-sparing and complementary approaches such as the Biceps Femoris Short Head (BiFeS) block and the Interspace Between the Popliteal Artery and the Capsule of the posterior Knee (IPACK) block for posterior knee analgesia. In light of this information, the aim of our study is to guide clinical practice by comparing the postoperative analgesic efficacy, motor function outcomes, and patient satisfaction associated with sciatic nerve, BiFeS, and IPACK block techniques-each administered as a supplement to the adductor canal block-in patients undergoing total knee arthroplasty, with the ultimate goal of determining the optimal block combination for postoperative pain control.
Eligibility
Inclusion Criteria4
- Patients classified as American Society of Anesthesiologists (ASA) physical status I-III
- Patients undergoing primary total knee arthroplasty
- Patients undergoing unilateral total knee arthroplasty
- Patients between 18 and 75 years of age
Exclusion Criteria11
- Patients classified as American Society of Anesthesiologists (ASA) physical status IV or higher
- Patients undergoing revision total knee arthroplasty
- Patients undergoing bilateral total knee arthroplasty
- Patients with neuromuscular disease
- Patients who decline to participate in the study
- Patients with cognitive dysfunction
- Patients with known drug allergies
- Patients with a history of local anesthetic systemic toxicity
- Patients with neurological dysfunction
- Patients with bleeding diathesis
- Pregnant patients
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Interventions
Adductor Canal Block An ultrasound-guided injection of 20 mL local anesthetic solution (10 mL 0.25% bupivacaine + 10 mL 0.9% saline) administered in the mid-portion of the adductor canal to provide motor-sparing analgesia to the anteromedial knee.
BiFeS Block (Biceps Femoris Short Head Block) An ultrasound-guided injection targeting the short head of the biceps femoris muscle to selectively block sensory branches contributing to posterior knee pain. A total of 20 mL of local anesthetic (10 mL 0.25% bupivacaine + 10 mL 0.9% saline) is administered.
IPACK Block An ultrasound-guided IPACK (Interspace Between the Popliteal Artery and the Capsule of the Posterior Knee) block using 20 mL of local anesthetic solution (10 mL 0.25% bupivacaine + 10 mL 0.9% saline) to provide posterior knee capsular analgesia while sparing motor function.
Sciatic Nerve Block An ultrasound-guided sciatic nerve block performed at the proximal thigh level using 20 mL of local anesthetic solution (10 mL 0.25% bupivacaine + 10 mL 0.9% saline) to provide posterior knee analgesia.
Locations(1)
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NCT07242170