Clamp Study to Estimate the Relative Potency of GZR33 Versus Insulin Degludec at Steady State

This study is comparing the strength (potency) of a new experimental insulin called GZR33 versus insulin degludec (a long-acting insulin already in use) in people with Type 1 diabetes. The study uses a specialized technique called a glucose clamp, which measures how much glucose the body needs to maintain steady blood sugar levels at different insulin doses. **You may be eligible if...** - You have had Type 1 diabetes for at least 12 months - You are 18 to 64 years old - Your HbA1c (average blood sugar level) is 9.0% or below - Your BMI is between 18.5 and 29.0 kg/m² - You have been on a stable insulin regimen for at least 2 months **You may NOT be eligible if...** - Your blood pressure falls outside normal ranges - You have other significant health conditions - You have had repeated severe low blood sugar episodes (more than 1 episode requiring help in the past 6 months) - You are unaware when your blood sugar is going low (hypoglycemia unawareness) - Your kidney function is reduced (eGFR below 60) Talk to your doctor to see if this trial is right for you.