RecruitingNot ApplicableNCT07243691

Study on the Therapeutic Effect of Different Infusion Times of Tislelizumab on Postoperative High-risk Hepatocellular Carcinoma


Sponsor

Sir Run Run Shaw Hospital

Enrollment

33 participants

Start Date

Dec 1, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

Study on the therapeutic effect of different infusion times on tislelizumab in high-risk postoperative hepatocellular carcinoma


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study looks at whether giving the immunotherapy drug tislelizumab as a shorter infusion (30 minutes) works just as well and is as safe as the standard longer infusion (60 minutes) after surgery for liver cancer. This could make treatment more convenient for patients. **You may be eligible if...** - You are 18 to 75 years old - You have been diagnosed with liver cancer (hepatocellular carcinoma) confirmed by biopsy - Your cancer was at an early to intermediate stage (BCLC stage A-B) and was surgically removed with no spread outside the liver - You have recovered well enough after surgery to start treatment **You may NOT be eligible if...** - You have HIV, active hepatitis B or C infection - You have serious autoimmune disease or other significant health conditions - You have received prior liver cancer treatment or immunotherapy - You are pregnant or breastfeeding Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGTislelizumab: 200mg, intravenous infusion, Q3W

Postoperative adjuvant therapy (maximum of 8 cycles, each cycle lasting 21 days): \- Tislelizumab: 200 mg, intravenous infusion, Q3W. Based on previous preclinical and clinical studies on circadian rhythms and adaptive immune responses, blood samples will be collected from patients at 05:00-07:00, 11:00-13:00, 17:00-19:00, and 23:00-01:00 (every 6 hours) to analyze the subset classification of peripheral blood lymphocytes. This will help map the immune circadian rhythm and determine the optimal injection time (which will then be used as the dosing time).


Locations(1)

Sir Run Run Shaw Hospital, Zhejiang University School of Medicine (Qingchun Campus) 3 Qingchun Road East, Shangcheng District, Hangzhou, Zhejiang, China

Hangzhou, Zhejiang, China

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NCT07243691


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