RecruitingNCT07243873

Synthetic PET From CT Improves Precision Diagnosis and Treatment of Lung Cancer: a Prospective, Observational, Multicenter Study


Sponsor

Shanghai Pulmonary Hospital, Shanghai, China

Enrollment

10,000 participants

Start Date

Dec 1, 2025

Study Type

OBSERVATIONAL

Conditions

Summary

This study aims to synthesise PET data that preserves biological relevance and adds clinical value to the diagnosis and prognosis of lung cancer by establishing anatomical-to-metabolic mapping based on paired diagnostic CT and FDG-PET scans, thereby prospectively validating the clinical utility of the model.


Eligibility

Min Age: 18 YearsMax Age: 85 Years

Plain Language Summary

Simplified for easier understanding

This study tests whether AI can generate a virtual PET scan image from a regular CT scan for lung cancer patients. PET scans show cancer activity but are expensive and use radiation. If AI can create a reliable substitute from existing CT images, it could improve access to better cancer staging without additional scans. **You may be eligible if...** - You have non-small cell lung cancer (the most common type of lung cancer) - You are scheduled to have both a PET-CT scan and a tissue biopsy as part of your care - You are willing to sign an informed consent form **You may NOT be eligible if...** - You have a history of other cancers - Your scan images have significant quality problems - You do not have a confirmed tissue diagnosis of lung cancer Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DIAGNOSTIC_TESTPET-CT

A PET-CT scan is performed prior to initiating systemic treatment for the tumour.


Locations(5)

Affiliated Hospital of Zunyi Medical University

Zunyi, Guizhou, China

The First Affiliated Hospital of Nanchang University

Jiangxi, Nanchang, China

Shanghai East Hospital

Shanghai, Shanghai Municipality, China

Shanghai Pulmonary Hospital

Shanghai, Shanghai Municipality, China

Ningbo No.2 Hospital

Ningbo, Zhejiang, China

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NCT07243873


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