RecruitingPhase 4NCT07244003

Efficacy and Safety of the Met+SGLT-2i+GLP-1RA in Patients With Type 2 Diabetes With Poor Glycemic Control

Efficacy and Safety of the Triple Combination Therapy of Met/SGLT-2i/GLP-1RA or Other Oral Antidiabetic Drugs in Patients With Type 2 Diabetes Exhibiting Poor Glycemic Control


Sponsor

Hangzhou Zhongmei Huadong Pharmaceutical Co., Ltd.

Enrollment

430 participants

Start Date

Mar 29, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

The main objective of this study is to compare the efficacy and safety of the triple combination therapy of Met/SGLT-2i/GLP-1RA or other oral antidiabetic drugs in patients with type 2 diabetes exhibiting poor glycemic control.


Eligibility

Min Age: 18 YearsMax Age: 75 Years

Plain Language Summary

Simplified for easier understanding

This study tests whether adding a GLP-1 receptor agonist (a newer diabetes and weight-loss drug) to an existing combination of metformin and an SGLT-2 inhibitor can better control blood sugar in people with type 2 diabetes whose sugar levels remain too high on their current medications. **You may be eligible if...** - You are 18 to 75 years old with type 2 diabetes - Your BMI is 20 or above - You have been taking metformin (1000mg/day) plus an SGLT-2 inhibitor for at least 3 months - Your blood sugar (HbA1c) is still above 7.5% despite current treatment **You may NOT be eligible if...** - You have type 1 diabetes or other specific types of diabetes - You have severe kidney, liver, or heart disease - You have a history of pancreatitis or certain cancers (e.g., thyroid cancer) - You are pregnant or breastfeeding Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGMetformin

The dosage of metformin hydrochloride was consistent with baseline.

DRUGTriple Therapy of Other Oral Antidiabetic Drugs

The dosage of metformin hydrochloride was consistent with baseline. The usage and dosage of other hypoglycemic drugs were referred to their respective instructions.

DRUGganagliflozin

Ganagliflozin tablet : 50mg/d.

DRUGliraglutide

Liraglutide injection: 0.6 mg/d for the first week, 1.2 mg/d for the second week, and 1.8 mg/d after the third week.


Locations(1)

Tianjin Medical University General Hospital

Tianjin, Tianjin Municipality, China

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NCT07244003


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