Pistachio Intake and Nutrition-Related Outcomes in Individuals on GLP-1 Therapy
Dietary Pistachio Intake and Nutrition-Related Outcomes in Individuals Using GLP-1 Receptor Agonists: A Randomized Controlled Trial
Ian J. Neeland, MD
108 participants
Jan 29, 2026
INTERVENTIONAL
Conditions
Summary
In this study will look at how eating pistachios every day might affect participants weight, how healthy their diet is, and how they feel when eating. Investigators want to see if adding pistachios to meals for 12 weeks helps participants feel fuller, have more energy, and improve body composition. The study will include adults who have been taking GLP-1 medicines like semaglutide or tirzepatide for at least three months. Investigators also want to see if eating pistachios improves overall diet quality and health markers like tiredness and certain levels in blood.
Eligibility
Inclusion Criteria1
- Individuals with a BMI ≥30 kg/m2 or with a BMI ≥27 kg/m2 with at least one weight-related comorbidity who have been continuously using semaglutide or tirzepatide for three months for a clinical indication and remain on the therapy at the time of enrollment
Exclusion Criteria4
- No use or contraindication to use of a GLP-1 RA
- Known allergy to nuts
- Pregnant or breastfeeding
- Incarcerated
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Interventions
Participants will eat 2 ounces, or about 53 grams, of dry-roasted, unsalted pistachios each day along with their regular diet
DEXA scans will be used to measure body fat
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT07244445