Study of PRA-216 in Healthy Participants and Participants With Mild-to-Moderate Asthma

This early-phase study tests a new investigational drug called PRA-216 — first in healthy volunteers to check safety, then in people with mild-to-moderate asthma to see if it is safe, tolerated, and shows early signs of helping reduce asthma symptoms. **You may be eligible if...** - Phase 1 (healthy volunteers): You are 18 to 65 years old with no significant health conditions - Phase 2 (asthma group): You have a confirmed diagnosis of mild-to-moderate asthma - You are willing to attend all required study visits - You are able to provide written informed consent **You may NOT be eligible if...** - You have any significant medical condition (for the healthy volunteer phase) - You have severe asthma or asthma requiring frequent emergency care - You smoke or have a significant smoking history - You are pregnant or breastfeeding Talk to your doctor to see if this trial is right for you.