RecruitingNCT07245407

A Translational Study for Phenotyping and Endotyping Chinese Patients With NCFBE

A Multi-center Longitudinal Observation Translational Study to Evaluate Phenotypes, Endotypes and Biomarkers in Chinese Patients With NCFBE

Sponsor

AstraZeneca

Enrollment

320 participants

Start Date

Oct 27, 2025

Study Type

OBSERVATIONAL

Conditions

Non-cystic Fibrosis Bronchiectasis

Summary

Non-cystic ﬁbrosis bronchiectasis (NCFBE) is a chronic respiratory disease characterized by a clinical syndrome of chronic productive cough and recurrent respiratory infections in the presence of abnormal and permanent dilation of the bronchi. Recent epidemiological studies have clearly shown that the prevalence and incidence of NCFBE are quickly rising both in high- and low-income countries. With the increase of prevalence, bronchiectasis brings huge medical and economic burden to the society. In this study, the investigator will perform biomarker assessments and multi-omics analysis on NCFBE patients and healthy participants in China to validate the link of disease pathways to pathophysiological features and uncover the molecular endotypes behind clinical phenotypesof Chinese patients with NCFBE.

Eligibility

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying Participant Follow-up for people with non-cystic fibrosis bronchiectasis. The study is currently recruiting participants at 38 locations.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERParticipant Follow-up

This is a longitudinal multi-center, observational, translational study which includes patients with a physician diagnosis of NCFBE by chest HRCT and healthy controls (at baseline only). This study will consist of a baseline visit, a 6-month (site visit or telephone visit) and a 12-month visit as well as planned unscheduled visits for exacerbation events and one optional visit for bronchoscopy.Healthy participants will be only enrolled in the baseline visit and bronchoscopy visit.

Locations(38)

Beijing Chaoyang Hospital Affiliated to Capital Medical University

Beijing, Beijing Municipality, China

Beijing Hospital

Beijing, Beijing Municipality, China

Peking University People's Hospital

Beijing, Beijing Municipality, China

The Second Affiliated Hospital of Chongqing Medical University

Chongqing, Chongqing Municipality, China

The Second Affiliated Hospital of Fujian Medical University

Quanzhou, Fujian, China

Gansu Provincial Hospital

Lanzhou, Gansu, China

Shenzhen People's Hospital

Shenzhen, Guangdong, China

Affiliated Hospital of Guangdong Medical University"

Zhanjiang, Guangdong, China

The First Affiliated Hospital of Guangxi Medical University

Nanning, Guangxi, China

Guizhou Provincial People's Hospital

Guiyang, Guizhou, China

Henan Provincial People's Hospital

Zhengzhou, Henan, China

Zhengzhou People's Hospital

Zhengzhou, Henan, China

Shiyan Taihe Hospital

Shiya, Hubei, China

Xiangya Hospital of Central South University

Changsha, Hunan, China

The Affiliated Hospital of Xuzhou Medical University

Xuzhou, Jiangsu, China

The First Affiliated Hospital of Nanchang University

Nanchang, Jiangxi, China

The Second Hospital of Jilin University

Changchun, Jilin, China

Weifang People's Hospital

Weifang, Shandong, China

Huadong Hospital Affiliated to Fudan University