A Study to Test the Safety and Effects of Inhaled GDC-6988 in Participants With Muco-obstructive Disease

This study is testing whether an inhaled drug called GDC-6988 is safe and effective for people with muco-obstructive lung diseases — conditions where thick, sticky mucus blocks the airways — including bronchiectasis (non-cystic fibrosis type) and COPD with chronic bronchitis. **You may be eligible if...** - Your lung function (FEV1) is at least 40% of predicted normal - You have been on a stable treatment regimen for your lung condition for at least 28 days - Your condition has been stable for at least 28 days before screening - You are able to correctly use the inhaled device used in the study - If in certain study groups: you produce daily sputum and have bronchiectasis involving at least 2 lung lobes, OR you have COPD with chronic bronchitis **You may NOT be eligible if...** - Your lung function is too severely impaired (FEV1 below 40%) - Your condition has not been stable recently - You are unable to use the inhaler device correctly Talk to your doctor to see if this trial is right for you.