A Trial of Self-Adjusted Nitrous Versus Placebo During Office Vasectomy

This trial tests whether nitrous oxide (laughing gas) that patients can self-administer during a vasectomy procedure reduces pain and anxiety compared to a placebo (no active gas). Vasectomies are typically done in-office with only local anesthesia, and this study explores if nitrous oxide offers meaningful comfort benefits. **You may be eligible if...** - You are 18 to 85 years old - You are seeking a vasectomy for family planning - You can understand and complete study questionnaires - You are willing and able to provide written consent **You may NOT be eligible if...** - You are missing one or both testicles - You have had prior scrotal surgery that would complicate a vasectomy - You have conditions where nitrous oxide is unsafe (e.g., certain vitamin deficiencies, lung problems, recent ear surgery) Talk to your doctor to see if this trial is right for you.