Universal CAR-T Cell Therapy for MM

This study is testing a "universal" CAR-T cell therapy for people with multiple myeloma (a blood cancer that affects plasma cells in the bone marrow) who have already tried at least two prior treatments without lasting success. The therapy targets a protein called BCMA found on myeloma cells. **You may be eligible if...** - You have multiple myeloma that has come back or stopped responding to treatment - You have already tried at least two prior treatment regimens for myeloma - Your myeloma cells test positive for a protein called BCMA - Your heart, liver, kidney, and bone marrow are functioning adequately - Your doctors estimate you have at least 3 months to live **You may NOT be eligible if...** - You are pregnant or breastfeeding - You have a history of another cancer - You have an active autoimmune disease requiring treatment - You previously had a stem cell transplant from a donor - You have already received CAR-T cell therapy or other gene-modified cell treatments - You have already received a therapy specifically targeting the BCMA protein - You have severe heart disease - You have an active infection - You have active HIV, hepatitis B or C - You have a serious central nervous system condition Talk to your doctor to see if this trial is right for you.