Determination of Epigenetic Markers of Acute Myeloblastic Leukemia in Elderly Patients
Collection of Biological Samples for Research Purposes: Determination of Epigenetic Markers of Acute Myeloblastic Leukemia in Elderly Patients
Groupe Hospitalier de la Region de Mulhouse et Sud Alsace
30 participants
Jan 13, 2026
INTERVENTIONAL
Conditions
Summary
The main objective of this study is to identify epigenetic markers specific to abnormal myeloid cells in patients with acute myeloid leukemia (AML) by analyzing the methylation of circulating cell-free DNA in plasma.
Eligibility
Plain Language Summary
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Interventions
Methylation profiles will be analyzed and DNA regions (CpG sites) that show significant differences between healthy and pathological cells from bone marrow will be identified. These regions could serve as epigenetic markers for cells from patients with LAM, if they can be used by digital PCR. These differentially methylated CpG islands will be targeted for the design of specific primer and probe pairs for use in digital PCR. The markers will then be tested in circulating free DNA from blood.
Locations(2)
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NCT07250217