RecruitingNot ApplicableNCT07250217

Determination of Epigenetic Markers of Acute Myeloblastic Leukemia in Elderly Patients

Collection of Biological Samples for Research Purposes: Determination of Epigenetic Markers of Acute Myeloblastic Leukemia in Elderly Patients


Sponsor

Groupe Hospitalier de la Region de Mulhouse et Sud Alsace

Enrollment

30 participants

Start Date

Jan 13, 2026

Study Type

INTERVENTIONAL

Conditions

Summary

The main objective of this study is to identify epigenetic markers specific to abnormal myeloid cells in patients with acute myeloid leukemia (AML) by analyzing the methylation of circulating cell-free DNA in plasma.


Eligibility

Min Age: 60 Years

Plain Language Summary

Simplified for easier understanding

This study looks for biological markers in bone marrow and blood that could help identify or predict acute myeloid leukemia (AML, a blood cancer) in older patients, by comparing samples from AML patients with those from older adults having heart surgery (who do not have leukemia). **You may be eligible if...** - You are 60 years old or older - AML group: You have been newly diagnosed with AML and are scheduled to receive treatment with azacitidine - Control group: You are scheduled for heart surgery involving a sternotomy and have a normal recent blood count - You are able to provide written informed consent **You may NOT be eligible if...** - You have a blood disorder other than AML (AML group) - You have signs of leukemia in the central nervous system or only outside the bone marrow - You have previously been treated for AML (other than with hydroxyurea) - You have active HIV, hepatitis B, or hepatitis C - You have severe conditions that would interfere with the study - You are under legal protection or deprived of liberty Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DIAGNOSTIC_TESTEpigenetic markers

Methylation profiles will be analyzed and DNA regions (CpG sites) that show significant differences between healthy and pathological cells from bone marrow will be identified. These regions could serve as epigenetic markers for cells from patients with LAM, if they can be used by digital PCR. These differentially methylated CpG islands will be targeted for the design of specific primer and probe pairs for use in digital PCR. The markers will then be tested in circulating free DNA from blood.


Locations(2)

Groupe Hospitalier de la Région de Mulhouse et Sud Alsace

Mulhouse, Alsace, France

GHRMSA

Mulhouse, France

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NCT07250217


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