C. Difficile Toxin Levels in Stool From Healthy Individuals Following Standard of Care Antibiotic Treatment for CDI.

This multi-site observational study follows adults aged 18–75 who have recently completed antibiotic treatment for their first recurrence of Clostridioides difficile infection (CDI) — a gut infection causing severe diarrhea — to track whether the infection returns within 8 weeks. Researchers will also test stool samples for levels of C. difficile toxins at baseline, 2 weeks, and 8 weeks to explore whether toxin levels after treatment can predict who is at highest risk of a repeat infection. To be eligible, participants must have finished standard antibiotic therapy for their first rCDI no more than 5 days before enrollment and be symptom-free at the time of joining; those with active symptoms, planned additional CDI treatments, or significant chronic health conditions are excluded. Participation involves 4 clinic or remote visits over approximately 9 weeks and providing stool samples. This summary was prepared as patient-facing educational content using AI assistance.