Gut Microbiota in IBD With Comorbid Depressive Disorder
Gut Microbial Characteristics in Patients With Comorbid Inflammatory Bowel Disease and Depressive Disorder
Fang Tang
120 participants
Mar 16, 2025
OBSERVATIONAL
Conditions
Summary
Inflammatory bowel disease (IBD) is often comorbid with depressive disorder, and the development and progression of both conditions are closely related to the composition of gut microbiota and metabolites. However, studies investigating their comorbidity using microbiome and metabolomics approaches remain limited. This study aims to investigate the diversity changes in the gut microbiome and metabolome of patients with comorbid IBD and depressive disorder through multi-omics approaches, to identify specific microbial and metabolic signatures associated with the comorbidity of these two conditions, and to provide a molecular basis for elucidating the underlying mechanisms.
Eligibility
Inclusion Criteria16
- IBD with Depressive Disorder Group:
- Patients diagnosed with inflammatory bowel disease (ICD-10 codes: K50-K51).
- History of depressive disorder diagnosis or previous use of antidepressant medications.
- Age ≥ 18 years.
- Willingness to participate and provision of written informed consent.
- IBD without Depressive Disorder Group:
- Patients diagnosed with inflammatory bowel disease (ICD-10 codes: K50-K51).
- No history of depressive disorder diagnosis
- No previous use of antidepressant medications.
- Age ≥ 18 years.
- Willingness to participate and provision of written informed consent.
- Control Group:
- No history of inflammatory bowel disease, depressive disorder, or use of antidepressant medications.
- No gastrointestinal symptoms (e.g., diarrhea, constipation, abdominal pain) within the past 3 months, and no history of gastrointestinal diseases.
- Age ≥ 18 years.
- Willingness to participate and provision of written informed consent.
Exclusion Criteria4
- Presence of other major chronic diseases or infections (e.g., malignancy, hypertension, diabetes, coronary heart disease).
- Use of antibiotics or probiotic supplements within the past 6 months.
- Inability or difficulty in providing biological samples.
- Missing essential patient information.
Interventions
observational study with no assigned intervention
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT07252427