RecruitingNCT07252427

Gut Microbiota in IBD With Comorbid Depressive Disorder

Gut Microbial Characteristics in Patients With Comorbid Inflammatory Bowel Disease and Depressive Disorder

Sponsor

Fang Tang

Enrollment

120 participants

Start Date

Mar 16, 2025

Study Type

OBSERVATIONAL

Conditions

Depressive Disorder Inflammatory Bowel Disease

Summary

Inflammatory bowel disease (IBD) is often comorbid with depressive disorder, and the development and progression of both conditions are closely related to the composition of gut microbiota and metabolites. However, studies investigating their comorbidity using microbiome and metabolomics approaches remain limited. This study aims to investigate the diversity changes in the gut microbiome and metabolome of patients with comorbid IBD and depressive disorder through multi-omics approaches, to identify specific microbial and metabolic signatures associated with the comorbidity of these two conditions, and to provide a molecular basis for elucidating the underlying mechanisms.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This observational study examines how gut microbiota (the bacteria living in the intestines) differs between patients with inflammatory bowel disease (IBD, such as Crohn's disease or ulcerative colitis) who also have depression, those with IBD alone, and healthy individuals. Stool samples and data are collected to understand the gut-brain connection. **You may be eligible if...** - You are 18 or older - IBD with depression group: You have an IBD diagnosis and a history of depression or use of antidepressants - IBD without depression group: You have an IBD diagnosis and no history of depression or antidepressants - Healthy control group: You have no IBD, no depression, and no gastrointestinal symptoms in the past 3 months **You may NOT be eligible if...** - You have other major chronic illnesses such as cancer, heart disease, or diabetes - You have taken antibiotics or probiotic supplements in the past 6 months - You have difficulty providing biological samples - Key health information about you is missing Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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