RecruitingNot ApplicableNCT07191392

Intervention Effect of Temporal Interference Stimulation (TIS) on Depressive Disorder


Sponsor

The Second Hospital of Anhui Medical University

Enrollment

60 participants

Start Date

Sep 1, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

To investigate the effect of Temporal Interference Stimulation (TIS) on associative memory (AM) in patients with depressive disorder


Eligibility

Min Age: 12 YearsMax Age: 60 Years

Inclusion Criteria3

  • the patients were diagnosed by more than 2 psychiatrists and met the diagnostic criteria of DSM-5 for depression, and HAMD\>17, BSS\>6, PHQ-15\>5.
  • the age ranged from 18 to 65 years old, and the length of education was more than 5 years.
  • the visual acuity or corrected visual acuity is normal, right-handed, can cooperate with the completion of various experimental tests.

Exclusion Criteria3

  • accompanied by severe somatic diseases, such as severe heart, liver, renal insufficiency and so on.
  • accompanied by other neurological diseases, such as stroke, epilepsy and so on. pregnant and lactating women.
  • accompanied by other mental disorders, such as drug abuse, schizophrenia, schizophrenic affective

Interventions

DEVICETemporal Interference Stimulation (TIS)

The total stimulation duration was 30 minutes, including a 30-second current ramp-up at the beginning and a 30-second ramp-down at the end.

DEVICESham temporal interference stimulation (TIS)

Sham stimulation had only 30 seconds of current ramping-up and ramping-down at the beginning and end of the stimulation, respectively, to simulate the sensation of actual stimulation


Locations(2)

Anhui Medical University

Hefei, Anhui, China

Anhui Mental Health Center

Hefei, Anhui, China

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NCT07191392


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