Intervention Effect of Temporal Interference Stimulation (TIS) on Depressive Disorder

This study is testing a brain stimulation technique called temporal interference stimulation (TIS) — a non-invasive method that uses two low-level electrical currents to stimulate deeper brain areas — as a treatment for depression. **You may be eligible if...** - You are between 18 and 65 years old - You have been diagnosed with depression (major depressive disorder) by at least two psychiatrists according to standard DSM-5 criteria - Your depression scores on standard rating scales (HAMD > 17, BSS > 6, PHQ-15 > 5) are above the threshold - You have at least 5 years of education - You are right-handed with normal vision **You may NOT be eligible if...** - You have serious physical health problems (severe heart, liver, or kidney disease) - You have neurological conditions such as stroke or epilepsy - You are pregnant or breastfeeding - You have other mental health conditions such as schizophrenia or substance use disorder Talk to your doctor to see if this trial is right for you.