Effect of Pentoxifylline + CoQ10 vs CoQ10 Alone on Sperm Motility in Subfertile Men With Asthenozoospermia
Effect of Pentoxifylline Plus Coenzyme Q10 Combination Therapy Compared to Coenzyme Q10 Alone on Sperm Motility in Sub-fertile Male With Asthenozoospermia
Mst.Sumyara Khatun
56 participants
Oct 1, 2025
INTERVENTIONAL
Conditions
Summary
The goal of this clinical trial is to learn if drug Pentoxifylline plus Coenzyme Q10 work to treat asthenozoospermia in subfertile male. It will also learn about the safety of drug Pentoxifylline plus Coenzyme Q10. The main questions it aims to answer are: Does drug Pentoxifylline plus Coenzyme Q10 increase the motility of sperm in participants? What medical problems do participants have when taking drug Pentoxifylline plus Coenzyme Q10 ? Researchers will compare drug Pentoxifylline plus Coenzyme Q10 combination to Coenzyme Q10 alone to see if drug Pentoxifylline plus Coenzyme Q10 combination works better. Participants will: Experimental Group:Pentoxifylline 400mg twice dailyand Coenzyme Q10 100mg twice daily for 3 months. Comparator Group: Coenzyme Q10 100mg twice daily for 3 months Visit the clinic after three months of treatment for checkups and tests
Eligibility
Inclusion Criteria2
- Sub fertile men with asthenozoospermia(Total motility20% to less than 42%) according to WHO semen analysis,2021.
- Age 20-50 years.
Exclusion Criteria9
- Severe oligoasthenoteratozoospermia
- Any medical, endocrine and genetic disorders, history of chemotherapy or radiotherapy, genital infection, genital surgery.
- Antioxidants supplmentation in the last 3 months
- Drug, alcohol or substance abuse, psycho-sexual abnormalities.
- Any known hypersensitivity to xanthine related product, recent cerebral or retinal haemorrhage Severe oligoasthenoteratozoospermia
- Any medical, endocrine and genetic disorders, history of chemotherapy or radiotherapy, genital infection, genital surgery.
- Antioxidants supplmentation in the last 3 months
- Drug, alcohol or substance abuse, psycho-sexual abnormalities.
- Any known hypersensitivity to xanthine related product, recent cerebral or retinal haemorrhage
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Interventions
Participants will receive Coenzyme Q10 100 mg twice daily for 3 months
Participants will receive pentoxifylline 400mg twice daily plus coenzyme Q10 100mg twice daily for 3 months
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT07252518