RecruitingPhase 2NCT07257809

Herombopag Treated T-DM1 Induced Platelet Reduction

A Multicenter, Single-arm Exploratory Clinical Study Evaluating the Efficacy and Safety of T-DM1 in Patients With Breast Cancer Who Developed Thrombocytopenia.


Sponsor

Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University

Enrollment

56 participants

Start Date

Oct 13, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

This is a single-arm study planned to enroll 56 breast cancer patients who experienced grade 2 or higher thrombocytopenia following prior chemotherapy and achieved normalization (platelet count ≥100 × 109/L and ≥200 × 109/L) through intervention.


Eligibility

Min Age: 18 YearsMax Age: 75 Years

Plain Language Summary

Simplified for easier understanding

This study tests a drug called herombopag — which helps the body produce more platelets (blood cells that help with clotting) — in breast cancer patients who have developed low platelet counts (thrombocytopenia) as a side effect of a treatment called T-DM1. **You may be eligible if...** - You are 18 to 75 years old - You have breast cancer that was previously treated with neoadjuvant anti-HER2 therapy, and you are now receiving T-DM1 as adjuvant therapy - You developed a significant drop in platelet count (grade 2 or higher) during T-DM1 treatment **You may NOT be eligible if...** - You have a platelet disorder unrelated to your cancer treatment - You have liver disease or significant blood clotting problems - You are pregnant or breastfeeding Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGHerombopag Olamine Tablets

Herombopag 7.5 mg po qd,d1-14


Locations(1)

Sun Yat-sen Memorial Hospital

Guangzhou, Guangdong, China

View Full Details on ClinicalTrials.gov

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NCT07257809


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