RecruitingNCT07257835

Dupilumab Therapy for EGIDs

Dupilumab Therapy for Refractory Eosinophilic Gastrointestinal Disorders in Children


Sponsor

Children's Hospital of Fudan University

Enrollment

20 participants

Start Date

Jan 1, 2025

Study Type

OBSERVATIONAL

Conditions

Summary

This is a single-center observational study to investigate the efficacy and tolerability of dupilumab in children with refractory eosinophilic gastrointestinal disorders.


Eligibility

Min Age: 1 YearMax Age: 18 Years

Inclusion Criteria2

  • Clinical diagnosis of Refractory Peptic Ulcers
  • with Refractory Eosinophilic Gastrointestinal Disorders

Exclusion Criteria4

  • with Active Helicobacter pylori infection at present.
  • with Inflammatory bowel disease
  • with Parasite infection
  • with Cancer

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Interventions

DRUGDupilumab - Standard Dose

Dose: For patients with weight ≥ 15kg but \< 30kg, take 200mg each time, every two weeks; for those with weight ≤ 30kg but \< 60kg, take 300mg each time, every two weeks; for those with weight ≥ 60kg, take 300mg each time, once a week.

DEVICEsubcutaneous injection

Dose: For patients with weight ≥ 15kg but \< 30kg, take 200mg each time, every two weeks; for those with weight ≤ 30kg but \< 60kg, take 300mg each time, every two weeks; for those with weight ≥ 60kg, take 300mg each time, once a week.


Locations(1)

201102

Shanghai, China

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NCT07257835


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