RecruitingNCT07262515

Integrative Epidemiology of Prognosis in Patients With Acute Alcoholic Hepatitis at AP-HP


Sponsor

Assistance Publique - Hôpitaux de Paris

Enrollment

1,400 participants

Start Date

Jul 19, 2024

Study Type

OBSERVATIONAL

Conditions

Summary

Acute alcoholic hepatitis (AAH) is a severe liver disease that often occurs in individuals with prolonged excessive alcohol consumption. Patients face a high risk of liver failure, complications, and death, despite available treatments. Current prognostic scores based on blood tests provide limited accuracy and do not capture the full complexity of the disease. The purpose of this study is to improve the prediction of patient outcomes after a diagnosis of acute alcoholic hepatitis. By integrating clinical, biological, and histological information collected from the AP-HP data warehouse, the investigators aim to identify more reliable prognostic markers. This could help physicians better tailor treatments and improve survival of patients affected by this condition.


Eligibility

Min Age: 18 Years

Inclusion Criteria2

  • Adult patients (≥18 years)
  • Diagnosis of acute alcoholic hepatitis (ICD10 K701 or occurrence of the terms "HAA" (French translation of "AAH" or "hépatite alcoolique aiguë" (French translation of "acute alcoholic hepatitis") in a pathology report, followed by manual verification

Exclusion Criteria1

  • \- Patients younger than 18 years at diagnosis

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Locations(1)

Necker Hospital

Paris, France

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NCT07262515