RecruitingNot ApplicableNCT07263295

Evaluation of Diaphragmatic Function After Interscalene Block With Liposomal Bupivacaine

Evaluation of Diaphragmatic Function After Interscalene Brachial Plexus Block With Liposomal Bupivacaine: A Cohort Study

Sponsor

Zhejiang University

Enrollment

120 participants

Start Date

Dec 5, 2025

Study Type

INTERVENTIONAL

Conditions

Metacarpal fracture Radius Fracture Chronic Ulcer Diaphragmatic Function Peripheral Nerve Neurolysis Upper Extremity Ligament Injury

Summary

The study aims to evaluation the effects of Liposomal Bupivacaine on diaphragmatic function in patients undergoing upper limb surgery who receive Interscalene Brachial Plexus Block. A total of 120 eligible patients will be enrolled and divided into two groups: Group A will receive 20ml of 0.5% Hydrochloride Bupivacaine , while Group B will receive 10ml of 0.5% Hydrochloride Bupivacaine plus 10ml of Liposomal Bupivacaine. Assessments of diaphragmatic function, pulmonary function, and pain intensity will be performed before the block and at different time points after the block, with follow-up for adverse events. The study is scheduled to run from September 2025 to September 2026, with strict adherence to privacy protection and ethical guidelines.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a drug called 0.5% Hydrochloride Bupivacaine 10ml, a drug called 0.5% Hydrochloride Bupivacaine 20ml, and others for people with chronic ulcer, diaphragmatic function, and other related conditions. The study is currently recruiting participants at 1 location. People eligible for this study include aged 18 Years and older.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUG0.5% Hydrochloride Bupivacaine 20ml

0.5% Hydrochloride Bupivacaine 20ml for ISBPB

DRUG0.5% Hydrochloride Bupivacaine 10ml

0.5% Hydrochloride Bupivacaine 10ml for ISBPB

DRUGLiposomal Bupivacaine 10mL

Liposomal Bupivacaine 10mL for ISBPB

Locations(1)

The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, zhejiang 310000

Hangzhou, Zhejiang, China

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NCT07263295

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