RecruitingNCT07263490

PRIOR Study (Pre-eclampsia Risk In Oocyte Recipients)

PRIOR Study (Pre-eclampsia Risk In Oocyte Recipients) - Investigating Matching, Biomarkers and Outcomes.

Sponsor

Copenhagen University Hospital, Hvidovre

Enrollment

462 participants

Start Date

Oct 21, 2024

Study Type

OBSERVATIONAL

Conditions

Pre-Eclampsia Pre-Eclampsia; Complicating Pregnancy ART Neonatal Mortality Placental Abruption Gestational Diabetes Preterm Labor Intrauterine Growth Restriction (IUGR)Hypertensive Disorders of Pregnancy Oocyte Donation Pre-Eclampsia; Mild Pre-Eclampsia, Severe Pre-eclampsia or Eclampsia With Pre-existing Hypertension Neonatal Morbidity Post-partum Hemorrhage (PPH)

Summary

The aim of this prospective observational cohort study is to investigate the pathophysiological mechanisms behind and risk of pre-eclampsia in women pregnant after fertility treatment with oocyte donation. The participants are included in of of two cohorts. One includes women pregnant after oocyte donation whereas the other includes women pregnant after IVF treatment with autologous oocytes. Participants will be followed throughout pregnancy with blood samples, blood pressure, clinical controls and ultrasound examinations. Clinical outcomes will be registered post-partum.

Eligibility

Sex: FEMALEMin Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is investigating risk factors for preeclampsia — a serious pregnancy complication involving high blood pressure — specifically in women pregnant through egg (oocyte) donation, who are known to have a higher risk of this condition. **You may be eligible if...** - You are over 18 years old - You have a BMI under 35 - You are pregnant through oocyte (egg) donation — either single or multiple pregnancy - You are a first-time or previous mother **You may NOT be eligible if...** - You have HIV or hepatitis - You have pre-existing high blood pressure or chronic kidney disease - Your BMI is 35 or higher - You have a uterine malformation, unexplained vaginal bleeding, or ovarian cysts - You have certain hormonal tumors or uncontrolled thyroid disease - You have a history of breast cancer or carry BRCA gene mutations - You are currently breastfeeding or have received prior chemotherapy or pelvic radiation Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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