PRIOR Study (Pre-eclampsia Risk In Oocyte Recipients)
PRIOR Study (Pre-eclampsia Risk In Oocyte Recipients) - Investigating Matching, Biomarkers and Outcomes.
Copenhagen University Hospital, Hvidovre
462 participants
Oct 21, 2024
OBSERVATIONAL
Conditions
Summary
The aim of this prospective observational cohort study is to investigate the pathophysiological mechanisms behind and risk of pre-eclampsia in women pregnant after fertility treatment with oocyte donation. The participants are included in of of two cohorts. One includes women pregnant after oocyte donation whereas the other includes women pregnant after IVF treatment with autologous oocytes. Participants will be followed throughout pregnancy with blood samples, blood pressure, clinical controls and ultrasound examinations. Clinical outcomes will be registered post-partum.
Eligibility
Inclusion Criteria5
- Age \> 18 years
- BMI \< 35 kg/m2
- Normal wet smear within the past three years
- Both nulli- and multiparous
- Singletons and multiple gestations
Exclusion Criteria18
- Age \< 18 years
- BMI \> 35 kg/m2
- HIV/ hepatitis
- Essential hypertension
- Chronic kidney disease
- Undiagnosed vaginal bleeding
- Uterine malformations
- Persisting ovarian cysts
- Tumors in hypothalamus, pituitary, thyroid, or adrenal glands.
- Previous breast cancer
- Known BRCA 1 or 2 gene
- Unregulated thyroid disease
- Cardiovascular disease
- Breast feeding
- Present or previous chemotherapy/radiation therapy
- Present or previous malignant disease
- Smoking
- Alcohol/drug abuse
Locations(6)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT07263490