LLM-Guided Rehabilitation in Degenerative Knee Disease
The Effect of ChatGPT-5, Gemini 2.5 Pro, and DeepSeek V3.1 Guided Rehabilitation on Clinical Outcomes in Individuals With Degenerative Knee Disease
Kirsehir Ahi Evran Universitesi
80 participants
Nov 26, 2025
INTERVENTIONAL
Summary
This randomized, four-arm clinical trial will investigate the effects of large language model (LLM)-assisted exercise prescriptions integrated with conventional physiotherapy on pain, function and quality of life in adults with degenerative knee disease. Participants will be randomly assigned to conventional physiotherapy alone or to conventional physiotherapy plus an exercise program planned with the assistance of ChatGPT-5, Gemini 2.5 Pro, or DeepSeek V3.1. All participants will receive supervised outpatient physiotherapy two times per week for 8 weeks (16 sessions in total). Outcomes will be assessed at baseline and at the end of the 8-week intervention period by physiotherapists blinded to group allocation.
Eligibility
Inclusion Criteria6
- Age between 40 and 65 years.
- Clinical and radiographic diagnosis of degenerative knee disease in the target knee.
- Knee pain in the target knee for at least 3 months.
- Ability to bear weight on the target limb and perform the planned functional tests.
- Sufficient cognitive and physical capacity to participate in an 8-week supervised exercise program.
- Willingness to participate and ability to provide written informed consent.
Exclusion Criteria4
- Intra-articular corticosteroid or similar injection to the target knee within the previous 3 months.
- Knee surgery on the target knee within the previous 6 months.
- Severe malalignment of the knee or concomitant severe neurological disease and/or balance disorder that would interfere with safe testing or exercise.
- Pregnancy or any systemic disease that would contraindicate participation in the rehabilitation program according to the physician.
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Interventions
Supervised outpatient physiotherapy including hot pack (20 minutes), conventional TENS (100 Hz, 60 µs, 20 minutes), therapeutic ultrasound (1 MHz, 1.5 W/cm², 5 minutes) and a standardized knee exercise program (strengthening, range of motion, proprioceptive and functional exercises), delivered two times per week for 8 weeks (16 sessions in total).
Exercise selection and progression for the knee rehabilitation program supported by standardized prompts to the ChatGPT-5 large language model. All LLM-generated suggestions are reviewed for safety and appropriateness by physiotherapists before being implemented in supervised sessions.
Exercise selection and progression for the knee rehabilitation program supported by standardized prompts to the DeepSeek V3.1 large language model. All LLM-generated suggestions are reviewed for safety and appropriateness by physiotherapists before being implemented in supervised sessions.
Exercise selection and progression for the knee rehabilitation program supported by standardized prompts to the Gemini 2.5 Pro large language model. All LLM-generated suggestions are reviewed for safety and appropriateness by physiotherapists before being implemented in supervised sessions.
Locations(1)
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NCT07267962