Use of Preoperative Postbiotic Supplementation in Colorectal Cancer Surgery
Randomized Clinical Trial on the Use of Preoperative Postbiotic Supplementation in Colorectal Cancer Surgery
AC Camargo Cancer Center
164 participants
Jun 1, 2025
INTERVENTIONAL
Conditions
Summary
The treatment of colorectal cancer, in the absence of metastases, is primarily based on surgical removal. Colorectal surgery, which involves resecting part of the intestine and restoring intestinal continuity, carries a risk of complications. This study aims to evaluate whether oral supplementation with a postbiotic at a dose of 900 mg for 7 days prior to surgery reduces the rate of postoperative complications.
Eligibility
Inclusion Criteria3
- Individuals diagnosed with malignant neoplasm of the large intestine, specifically adenocarcinoma.
- Patients over 18 years of age, of both sexes.
- Patients who agree to participate in the study and sign the informed consent form.
Exclusion Criteria3
- Emergency or urgent surgeries.
- Cytoreductive surgeries involving intraoperative intraperitoneal chemotherapy.
- Extended surgeries for the treatment of recurrent tumors.
Interventions
Butyrate directly influences the gastrointestinal microbiota and exhibits potent anti-inflammatory effects by locally inhibiting inflammatory mediators in the intestinal epithelium, thereby enhancing mucosal barrier integrity. It also mitigates excessive inflammation through the modulation of immune cells, promoting the activity of M2 macrophages and regulatory T cells. Furthermore, butyrate is thought to modulate intestinal receptor hypersensitivity, leading to reduced intraluminal pressure and improved peristaltic function. This mechanism may underlie its therapeutic role in clinical conditions associated with diarrhea and in preventing the loss of water, sodium, chloride, and potassium.
Participants will receive three oral capsules per day, containing no active substance and identical in appearance to the study capsules, for seven consecutive days.
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT07268846