RecruitingNot ApplicableNCT07269093

Efficacy in Preventing Hypertrophic Scars: A Randomised Controlled Trial Comparing Chitosan Cream, Silicone Gel & Olive Oil


Sponsor

Universiti Sains Malaysia

Enrollment

120 participants

Start Date

Dec 21, 2025

Study Type

INTERVENTIONAL

Summary

The goal of this clinical trial is to compare the efficacy of three different topical applications in preventing hypertrophic scars in adults with scars healed after suturing. The main question it aims to answer is: Is Chitosan cream effective in preventing hypertrophic scars? Researchers will compare Chitosan cream with silicone gel and olive oil to see if there is any difference in their efficacies. Participants will be randomly assigned to three groups, with each group using a different topical application. They will be instructed to: * apply the topical application on their scar twice a day for 8 weeks * attend follow-up visits at 4, 12 and 24 weeks for a doctor to assess their scar and take clinical photographs * immediately inform the researcher if they experience any side effects


Eligibility

Min Age: 18 YearsMax Age: 65 Years

Inclusion Criteria2

  • Patients with traumatic or surgical wounds which have healed by primary intention within 14 days
  • Length of scar at least 3cm

Exclusion Criteria5

  • Patients with seafood allergy
  • Patients with scar from wounds that were complicated by infection or wound breakdown
  • Patients who have undergone scar treatment by other modalities
  • Patients with history of keloids / hypertrophic scars
  • Pregnant patients

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Interventions

DEVICEChitosan cream

Application of Chitosan cream twice daily for 8 weeks

DEVICESilicone Gel

Application of silicone gel twice a day for 8 weeks

DEVICEOlive Oil Topical Oil

Application of olive oil twice daily for 8 weeks


Locations(3)

Hospital Raja Perempuan Zainab II

Kota Bharu, Kelantan, Malaysia

Hospital Pakar Universiti Sains Malaysia

Kubang Kerian, Kelantan, Malaysia

Hospital Kuala Lumpur

Kuala Lumpur, Kuala Lumpur, Malaysia

View Full Details on ClinicalTrials.gov

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NCT07269093