Efficacy in Preventing Hypertrophic Scars: A Randomised Controlled Trial Comparing Chitosan Cream, Silicone Gel & Olive Oil
Universiti Sains Malaysia
120 participants
Dec 21, 2025
INTERVENTIONAL
Summary
The goal of this clinical trial is to compare the efficacy of three different topical applications in preventing hypertrophic scars in adults with scars healed after suturing. The main question it aims to answer is: Is Chitosan cream effective in preventing hypertrophic scars? Researchers will compare Chitosan cream with silicone gel and olive oil to see if there is any difference in their efficacies. Participants will be randomly assigned to three groups, with each group using a different topical application. They will be instructed to: * apply the topical application on their scar twice a day for 8 weeks * attend follow-up visits at 4, 12 and 24 weeks for a doctor to assess their scar and take clinical photographs * immediately inform the researcher if they experience any side effects
Eligibility
Inclusion Criteria2
- Patients with traumatic or surgical wounds which have healed by primary intention within 14 days
- Length of scar at least 3cm
Exclusion Criteria5
- Patients with seafood allergy
- Patients with scar from wounds that were complicated by infection or wound breakdown
- Patients who have undergone scar treatment by other modalities
- Patients with history of keloids / hypertrophic scars
- Pregnant patients
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Interventions
Application of Chitosan cream twice daily for 8 weeks
Application of silicone gel twice a day for 8 weeks
Application of olive oil twice daily for 8 weeks
Locations(3)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT07269093