RecruitingPhase 2NCT07269210

A Study of Solbinsiran (LY3561774) in Participants With Severe Hypertriglyceridemia

A Phase 2, Randomized, Double-Blind, Placebo-Controlled Study to Investigate the Efficacy and Safety of LY3561774 (Solbinsiran) in Adults With Severe Hypertriglyceridemia

Sponsor

Eli Lilly and Company

Enrollment

60 participants

Start Date

Dec 8, 2025

Study Type

INTERVENTIONAL

Conditions

Severe Hypertriglyceridemia

Summary

The purpose of this study is to evaluate the safety and efficacy of solbinsiran in lowering triglycerides and other lipid measures compared to placebo in participants with severe hypertriglyceridemia. Participants will receive two subcutaneous injections.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a drug called Placebo and a drug called Solbinsiran for people with severe hypertriglyceridemia. The study is currently recruiting participants at 41 locations. People eligible for this study include aged 18 Years and older.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGSolbinsiran

Administered SC

DRUGPlacebo

Administered SC

Locations(41)

Onyx Clinical Research

Phoenix, Arizona, United States

Synexus Clinical Research US, Inc./Orange Grove Family Practice

Tucson, Arizona, United States

National Heart Institute

Beverly Hills, California, United States

Ark Clinical Research

Long Beach, California, United States

Catalina Research Institute, LLC

Montclair, California, United States

Valley Clinical Trials, LLC dba Flourish Research

Northridge, California, United States

CMR of Greater New Haven, LLC

Hamden, Connecticut, United States

Northeast Research Institute - Downtown Office

Jacksonville, Florida, United States

Novera Clinical Research

Miami, Florida, United States

Inpatient Research Clinic

Miami Lakes, Florida, United States

Clinical Site Partners, LLC dba Flourish Research

Winter Park, Florida, United States

Great Lakes Clinical Trials - Ravenswood

Chicago, Illinois, United States

Investigators Research Group

Brownsburg, Indiana, United States

Saint Elizabeth Healthcare - Saint Elizabeth Covington Hospital

Covington, Kentucky, United States

Flourish Research - Bowie

Bowie, Maryland, United States

University of Massachusetts Chan Medical School

Worcester, Massachusetts, United States

AB Clinical Trials

Las Vegas, Nevada, United States

Clinical Research of Philadelphia

Pennington, New Jersey, United States

Weill Cornell Medical College

New York, New York, United States

Icahn School of Medicine at Mount Sinai

New York, New York, United States

Cardiovascular Specialists of Willowbrook

Houston, Texas, United States

Southern Endocrinology Associates

Mesquite, Texas, United States

American Research Corporation at Texas Liver Institute

San Antonio, Texas, United States

Endeavor Clinical Trials

San Antonio, Texas, United States

Stroobants Cardiovascular Center

Lynchburg, Virginia, United States

TPMG (Tidewater Physicians Multispecialty Group) Clinical Research

Newport News, Virginia, United States

Carilion Clinic

Roanoke, Virginia, United States

Eastside Research Associates

Redmond, Washington, United States

UW Medicine Diabetes Institute

Seattle, Washington, United States

Ecogene-21

Chicoutimi, Canada

C.I.C. Mauricie inc.

Trois-Rivières, Canada

ARC Biosystems

Vancouver, Canada

Peking University Third Hospital

Beijing, China

Sichuan Provincial People's Hospital

Chengdu, China

Guangdong Provincial People's Hospital

Guangzhou, China

The First Affiliated Hospital of Henan University of Science &Technology

Luoyang, China

Zhongshan Hospital,Fudan University

Shanghai, China

The Affiliated Hospital of Xuzhou Medical College

Xuzhou, China

The Institute of Medical Science, Asahi Life Foundation

Chūōku, Japan

Takai Internal Medicine Clinic

Kamakura-shi, Japan

Medical Corporation Heishinkai OCROM Clinic

Suita-shi, Japan

View Full Details on ClinicalTrials.gov

For the most up-to-date information, visit the official listing.

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NCT07269210

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