RecruitingNCT07270172

The MICRON Study - A Steno 1 Substudy

Multifactorial Intervention to Reduce Cardiac and Renal Oxygen Need in Type 1 Diabetes (the MICRON Study) - A Steno 1 Substudy

Sponsor

University of Aarhus

Enrollment

40 participants

Start Date

Oct 27, 2025

Study Type

OBSERVATIONAL

Conditions

Type 1 Diabetes Mellitus

Summary

The goal of this observational study is to compare cardiac and renal oxygen consumption among subjects with type 1 diabetes treated with either multifactorial intervention or according to the current standard care. Participants are recruited from a main study /the Steno1 study) responsible for the intervention. The main questions it aims to answer are if a multifactorial intervention in subjects with type 1 diabetes targeting cardiovascular and renal risk factors, will reduce cardiac and renal oxygen demand. Participants will undergo the following examinations at 0-month, 6-month, and 24-month after enrolling in the main study: * Measurement of cardiac and real oxygen consumption (\[11C\]acetate PET/CT-scan) * Measurement of kidney function (\[99mTc\]DTPA GFR measurement) * Measurement of markers of heart and kidney disease in blood and urine samples.

Eligibility

Min Age: 40 Years

Plain Language Summary

Simplified for easier understanding

This study, called MICRON, is looking at kidney health in people who have had type 1 diabetes for a long time and already have at least one serious complication such as kidney disease, heart disease, or severe obesity. Researchers want to understand how small kidney blood vessel changes occur over time. **You may be eligible if...** - You are 40 years or older - You have had type 1 diabetes for more than 10 years - You have kidney disease, a history of heart attack or stroke, heart failure, or a BMI above 35 - You are already enrolled or eligible for the broader Steno 1 study **You may NOT be eligible if...** - You have type 2 diabetes or another form of diabetes - You do not meet the kidney or cardiovascular complication criteria - You are not able to attend study visits at a participating center Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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